A mellékvesekéreg-carcinoma molekuláris patogenezise

Translated title of the contribution: Pathogenesis of adrenocortical cancer

Diána Szabó, Adrienn Zsippai, Melinda Bendes, Zsófia Tömböl, Péter M. Szabó, Károly Rácz, Péter Igaz

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Adrenocortical cancer is a rare tumor with poor prognosis. Whereas most cases occur in a sporadic setting, there are very rare hereditary forms that are important for the understanding of tumor pathogenesis. The hereditary syndromes associated with adrenocortical cancer are: Li-Fraumeni's syndrome, Beckwith-Wiedemann's syndrome and familial adenomatous polyposis, whereas multiple endocrine neoplasia type 1, Carney's complex and McCune-Albright's syndrome mostly predispose to benign adrenocortical tumors. Overexpression of insulin like growth factor 2, activation of Wnt/β-catenin and cAMP-protein kinase A signaling, as well as mutations of p53 and MEN1 genes are regarded as major pathogenetic mechanisms. Options for medical treatment of adrenocortical cancer are rather limited. Recently published molecular-bioinformatical studies have revealed several previously unknown pathogenetic pathways that may even represent potential drug targets. In this study, the pathogenesis of hereditary tumor syndromes, the alterations in sporadic tumors and the most recent molecular-bioinformatical observations are discussed.

Original languageHungarian
Pages (from-to)1163-1170
Number of pages8
JournalOrvosi hetilap
Volume151
Issue number29
DOIs
Publication statusPublished - Jul 1 2010

    Fingerprint

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Szabó, D., Zsippai, A., Bendes, M., Tömböl, Z., Szabó, P. M., Rácz, K., & Igaz, P. (2010). A mellékvesekéreg-carcinoma molekuláris patogenezise. Orvosi hetilap, 151(29), 1163-1170. https://doi.org/10.1556/OH.2010.28931