Pathogenesis and management of alcoholic liver injury

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The present paper is devoted to overview the basic concepts of ethanol- induced hepatic injury and therapeutic modalities by which alcoholic liver disease can be alleviated. The role of alcohol dehydrogenase of both hepatic and gastric origin as well as the importance of the number one metabolite acetaldehyde are discussed, furthermore the effects of microsomal ethanol oxidizing system are also described. The features of the major clinicopathological consequences of alcohol abuse fatty liver, alcoholic hepatitis are briefly outlined, and the basic pathogenetic mechanisms that lead to cirrhosis - cell necrosis, regeneration and fibroplasia - are shown. The understanding of the pathophysiology of alcohol-induced liver injury may improve the therapy with drugs and nutritional factors, and allow successful prevention through the early recognition of heavy drinkers before their social or medical disintegration. In the management of alcoholic liver diseases, among the true hepatoprotective agents a naturally occurring flavonoid silymarin and an active methyl-donor metabolite S-adenosyl-L- methionine seem to be promising. An antifibrotic treatment with colchicine might also be of importance. Further prospective, well-designed, controlled clinical trials are still warranted to evaluate real efficacy of these drugs. The hepatic consequences of alcohol abuse may be treatable, however, prevention would be the true resolution of the major global health problem of alcoholism.

Original languageEnglish
Pages (from-to)325-350
Number of pages26
JournalActa Physiologica Hungarica
Volume80
Issue number1-4
Publication statusPublished - 1992

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Alcoholism
Alcoholic Liver Diseases
Liver
Wounds and Injuries
Silymarin
Alcoholic Hepatitis
S-Adenosylmethionine
Acetaldehyde
Alcohol Dehydrogenase
Controlled Clinical Trials
Colchicine
Fatty Liver
Flavonoids
Regeneration
Stomach
Fibrosis
Ethanol
Necrosis
Alcohols
Drug Therapy

ASJC Scopus subject areas

  • Physiology

Cite this

Pathogenesis and management of alcoholic liver injury. / Pár, A.

In: Acta Physiologica Hungarica, Vol. 80, No. 1-4, 1992, p. 325-350.

Research output: Contribution to journalArticle

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