Pathobiology of highly pathogenic avian influenza virus (H5N1) infection in mute swans (Cygnus olor)

Nimród Pálmai, K. Erdélyi, A. Bálint, Lázár Márton, A. Dán, Zoltán Deim, K. Ursu, Brandon Z. Löndt, Ian H. Brown, Róbert Glávits

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The results of pathological, virological and polymerase chain reaction examinations carried out on 35 mute swans (Cygnus olor) that succumbed to a highly pathogenic avian influenza virus (H5N1) infection during an outbreak in Southern Hungary are reported. The most frequently observed macroscopic lesions included: haemorrhages under the epicardium, in the proventricular and duodenal mucosa and pancreas; focal necrosis in the pancreas; myocardial degeneration; acute mucous enteritis; congestion of the spleen and lung, and the accumulation of sero-mucinous exudate in the body cavity. Histopathological lesions comprised: lymphocytic meningo-encephalomyelitis accompanied by gliosis and occasional perivascular haemorrhages; multi-focal myocardial necrosis with lympho-histiocytic infiltration; pancreatitis with focal necrosis; acute desquamative mucous enteritis; lung congestion and oedema; oedema of the tracheal mucosa and, in young birds, the atrophy of the bursa of Fabricius as a result of lymphocyte depletion and apoptosis. The observed lesions and the moderate to good body conditions were compatible with findings in acute highly pathogenic avian influenza infections of other bird species reported in the literature. Skin lesions and lesions typical for infections caused by strains of lower pathogenicity (low pathogenic avian influenza virus) such as emaciation or fibrinous changes in the reproductive and respiratory organs, sinuses and airsacs were not observed. The H5N1 subtype avian influenza virus was isolated in embryonated fowl eggs from all cases and it was identified by classical and molecular virological methods.

Original languageEnglish
JournalAvian Pathology
Volume36
Issue number3
DOIs
Publication statusPublished - Jun 2007

Fingerprint

Cygnus olor
Influenza in Birds
Virus Diseases
Orthomyxoviridae
Influenza A virus
lesions (animal)
necrosis
Necrosis
Enteritis
enteritis
pancreas
infection
edema
Birds
mucosa
hemorrhage
Pancreas
Edema
Mucous Membrane
lungs

ASJC Scopus subject areas

  • Immunology
  • veterinary(all)

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Pathobiology of highly pathogenic avian influenza virus (H5N1) infection in mute swans (Cygnus olor). / Pálmai, Nimród; Erdélyi, K.; Bálint, A.; Márton, Lázár; Dán, A.; Deim, Zoltán; Ursu, K.; Löndt, Brandon Z.; Brown, Ian H.; Glávits, Róbert.

In: Avian Pathology, Vol. 36, No. 3, 06.2007.

Research output: Contribution to journalArticle

Pálmai, Nimród ; Erdélyi, K. ; Bálint, A. ; Márton, Lázár ; Dán, A. ; Deim, Zoltán ; Ursu, K. ; Löndt, Brandon Z. ; Brown, Ian H. ; Glávits, Róbert. / Pathobiology of highly pathogenic avian influenza virus (H5N1) infection in mute swans (Cygnus olor). In: Avian Pathology. 2007 ; Vol. 36, No. 3.
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