Path finding by tube morphogenesis in an amoeboid organism

Toshiyuki Nakagaki, Hiroyasu Yamada, A. Tóth

Research output: Contribution to journalArticle

194 Citations (Scopus)

Abstract

We have studied how the plasmodium of Physarum polycephalum, a large amoeboid cell, is able to track the shortest path between two selected points in a labyrinth. When nutrients are supplied at these points to a sheet-like plasmodium extended fully in a maze, the organism forms a single tube which connects the two sites via the shortest route. During the path finding, plasmodial parts in dead ends of the maze shrink and finally the tube with the minimum-length is selected from the existing possibilities. A simple cellular mechanism based on interacting cellular rhythms may describe the experimental observations.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalBiophysical Chemistry
Volume92
Issue number1-2
DOIs
Publication statusPublished - Sep 30 2001

Fingerprint

Plasmodium
Morphogenesis
organisms
Nutrients
Organism Forms
Physarum polycephalum
labyrinth
tubes
rhythm
nutrients
Inner Ear
routes
Food
cells

Keywords

  • Amoeboid movement
  • Maze
  • Morphogenesis
  • Optimization
  • Oscillation
  • Physarum

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Biophysics

Cite this

Path finding by tube morphogenesis in an amoeboid organism. / Nakagaki, Toshiyuki; Yamada, Hiroyasu; Tóth, A.

In: Biophysical Chemistry, Vol. 92, No. 1-2, 30.09.2001, p. 47-52.

Research output: Contribution to journalArticle

Nakagaki, Toshiyuki ; Yamada, Hiroyasu ; Tóth, A. / Path finding by tube morphogenesis in an amoeboid organism. In: Biophysical Chemistry. 2001 ; Vol. 92, No. 1-2. pp. 47-52.
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