Passive avoidance performance correlates with catecholamine turnover in discrete limbic brain regions

Gábor L. Kovács, Dirk H.G. Versteeg, E. Ronald de Kloet, Béla Bohus

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Abstract

Experimentally naive male rats were sequentially tested for an exploratory (open-field) and a one-trial learning passive avoidance behavior. Subsequently, α-MPT-induced disappearance of noradrenaline (NA) and dopamine (DA) was determined in microdissected brain regions. The animals were classified as good or poor avoiders on the basis of their performance in passive avoidance retention test. Trained controls were subjected to the same training except of electric foot-shock during the learning trial. The rate constant of NA disappearance was higher in the hippocampal dentate gyrus of the good vs. poor avoiders. In the good avoiders, the rate constant of DA disappearance was significantly higher in the central nucleus of the amygdala. The different turnover of catecholamines in the dorsal hippocampus and the amygdala in relation to passive avoidance performance suggests that individual differences in memory and/or learning may correlate with the catecholamine turnover of certain limbic structures.

Original languageEnglish
Pages (from-to)1109-1116
Number of pages8
JournalLife Sciences
Volume28
Issue number10
DOIs
Publication statusPublished - Mar 9 1981

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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