Parvalbumin-positive basket cells differentiate among hippocampal pyramidal cells

Sang Hun Lee, Ivan Marchionni, Marianne Bezaire, Csaba Varga, Nathan Danielson, Matthew Lovett-Barron, Attila Losonczy, Ivan Soltesz

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133 Citations (Scopus)

Abstract

CA1 pyramidal cells (PCs) are not homogeneous but rather can be grouped by molecular, morphological, and functional properties. However, less is known about synaptic sources differentiating PCs. Using paired recordings invitro, two-photon Ca2+ imaging invivo, and computational modeling, we found thatparvalbumin-expressing basket cells (PVBCs) evoked greater inhibition in CA1 PCs located in the deep compared to superficial layer of stratum pyramidale. In turn, analysis of reciprocal connectivity revealed more frequent excitatory inputs to PVBCs bysuperficial PCs, demonstrating bias in target selection by both the excitatory and inhibitory local connections in CA1. Additionally, PVBCs further segregated among deep PCs, preferentially innervating the amygdala-projecting PCs but receiving preferential excitation from the prefrontal cortex-projecting PCs, thus revealing distinct perisomatic inhibitory interactions between separate output channels. These results demonstrate the presence of heterogeneous PVBC-PC microcircuits, potentially contributing to the sparse and distributed structure of hippocampal network activity.

Original languageEnglish
Pages (from-to)1129-1144
Number of pages16
JournalNeuron
Volume82
Issue number5
DOIs
Publication statusPublished - Jun 4 2014

ASJC Scopus subject areas

  • Neuroscience(all)

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    Lee, S. H., Marchionni, I., Bezaire, M., Varga, C., Danielson, N., Lovett-Barron, M., Losonczy, A., & Soltesz, I. (2014). Parvalbumin-positive basket cells differentiate among hippocampal pyramidal cells. Neuron, 82(5), 1129-1144. https://doi.org/10.1016/j.neuron.2014.03.034