Partial-volume effect and a partial-volume correction for the NanoPET/CT™ preclinical PET/CT scanner

Istvan Szanda, Lefteris Livieratos, G. Patay, Charalampos Tsoumpas, Kavitha Sunassee, Gregory E. Mullen, Gabor Nemeth, Peter Major, Paul K. Marsden

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The partial-volume effect (PVE) can compromise the quantitative accuracy of preclinical positron emission tomogprahy (PET) images. We investigated this effect by simulating a NEMA NU4 mouse Image Quality Phantom (including calculation of a spatially variant position-dependent point spread function (PSF) ) as well as measuring it. Three different types of deconvolution-based partial- volume corrections were applied: the Lucy-Richardson (LR), Van Cittert (VC) and Wiener (WNR) algorithms. For simulation and phantom measurement, partial-volume correction was applied. Based on optimal parameters the same methods were used to correct data of a mouse study acquired with the NanoPET/CT™ preclinical scanner (Mediso Ltd. Budapest, Hungary and and Bioscan Inc., Washington DC, USA). The algorithms used successfully improve the values of recovery coefficients to varying extents both in simulation and measurement. The preliminary mouse study shows improvement in quantification. Full validation is subject to further investigation.

Original languageEnglish
Title of host publicationIEEE Nuclear Science Symposium Conference Record
Pages3605-3609
Number of pages5
DOIs
Publication statusPublished - 2012
Event2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011 - Valencia, Spain
Duration: Oct 23 2011Oct 29 2011

Other

Other2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011
CountrySpain
CityValencia
Period10/23/1110/29/11

Fingerprint

scanners
mice
positrons
Electrons
Hungary
point spread functions
simulation
recovery
coefficients

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

Cite this

Szanda, I., Livieratos, L., Patay, G., Tsoumpas, C., Sunassee, K., Mullen, G. E., ... Marsden, P. K. (2012). Partial-volume effect and a partial-volume correction for the NanoPET/CT™ preclinical PET/CT scanner. In IEEE Nuclear Science Symposium Conference Record (pp. 3605-3609) https://doi.org/10.1109/NSSMIC.2011.6153678

Partial-volume effect and a partial-volume correction for the NanoPET/CT™ preclinical PET/CT scanner. / Szanda, Istvan; Livieratos, Lefteris; Patay, G.; Tsoumpas, Charalampos; Sunassee, Kavitha; Mullen, Gregory E.; Nemeth, Gabor; Major, Peter; Marsden, Paul K.

IEEE Nuclear Science Symposium Conference Record. 2012. p. 3605-3609.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Szanda, I, Livieratos, L, Patay, G, Tsoumpas, C, Sunassee, K, Mullen, GE, Nemeth, G, Major, P & Marsden, PK 2012, Partial-volume effect and a partial-volume correction for the NanoPET/CT™ preclinical PET/CT scanner. in IEEE Nuclear Science Symposium Conference Record. pp. 3605-3609, 2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011, Valencia, Spain, 10/23/11. https://doi.org/10.1109/NSSMIC.2011.6153678
Szanda I, Livieratos L, Patay G, Tsoumpas C, Sunassee K, Mullen GE et al. Partial-volume effect and a partial-volume correction for the NanoPET/CT™ preclinical PET/CT scanner. In IEEE Nuclear Science Symposium Conference Record. 2012. p. 3605-3609 https://doi.org/10.1109/NSSMIC.2011.6153678
Szanda, Istvan ; Livieratos, Lefteris ; Patay, G. ; Tsoumpas, Charalampos ; Sunassee, Kavitha ; Mullen, Gregory E. ; Nemeth, Gabor ; Major, Peter ; Marsden, Paul K. / Partial-volume effect and a partial-volume correction for the NanoPET/CT™ preclinical PET/CT scanner. IEEE Nuclear Science Symposium Conference Record. 2012. pp. 3605-3609
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