Partial lesion of the serotonergic system by a single dose of MDMA results in behavioural disinhibition and enhances acute MDMA-induced social behaviour on the social interaction test

Romeo D. Ando, Anita Benko, Linda Ferrington, Eszter Kirilly, Paul A T Kelly, G. Bagdy

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The acute effects of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) on anxiety-related behaviours were studied using indices of social interaction in Dark Agouti (DA) both drug naive rats and those pretreated with MDMA (15 mg/kg i.p.) 3 weeks earlier. The functional neuroanatomy of these MDMA effects was visualised using 2-deoxyglucose imaging of local cerebral glucose use (LCMRglu), whilst MDMA-induced serotonergic neurotoxicity was measured by radioligand binding with [3H]paroxetine. Acute MDMA alone markedly decreased most typical elements of social interaction but increased adjacent lying, a behaviour that also contains social elements. In animals pre-exposed to MDMA, decreased [3H]paroxetine binding indicated serotonergic terminal depletion, and in these animals significant increases in locomotor activity, exploratory behaviour and aggressive behaviour were found. Both behavioural effects and also the metabolic activation induced by acute MDMA were potentiated in rats previously exposed to the drug. In conclusion, a single dose of MDMA caused marked changes in social behaviour acutely that might be interpreted either as a decrease or increase in anxiety. Three weeks after MDMA a behavioural disinhibition similar to psychomotor agitation, a symptom connected to depression or mania, and a sensitization to the acute effects of MDMA are apparent in both the behavioural and brain metabolic effects of the drug.

Original languageEnglish
Pages (from-to)884-896
Number of pages13
JournalNeuropharmacology
Volume50
Issue number7
DOIs
Publication statusPublished - Jun 2006

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N-Methyl-3,4-methylenedioxyamphetamine
Social Behavior
Interpersonal Relations
Paroxetine
Anxiety
Pharmaceutical Preparations
Neuroanatomy
Psychomotor Agitation
Exploratory Behavior
Deoxyglucose
Locomotion
Bipolar Disorder

Keywords

  • 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy)
  • Anxiety
  • Depression
  • Impulsivity
  • Local cerebral glucose utilization
  • Social behaviour

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

Partial lesion of the serotonergic system by a single dose of MDMA results in behavioural disinhibition and enhances acute MDMA-induced social behaviour on the social interaction test. / Ando, Romeo D.; Benko, Anita; Ferrington, Linda; Kirilly, Eszter; Kelly, Paul A T; Bagdy, G.

In: Neuropharmacology, Vol. 50, No. 7, 06.2006, p. 884-896.

Research output: Contribution to journalArticle

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