Partial depletion and altered distribution of synaptic zinc in the rat hippocampus after treatment with sodium diethyldithiocarbamate

Péter Szerdahelyi, Péter Kása

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16 Citations (Scopus)


A single injection with sodium diethyldithiocarbamate (SDEDTC, 1000 mg/kg i.p.) resulted within 1 h in a significant diminution of hippocampal (-23.9%) and cortical (-13.2%) zinc level, as revealed by atomic absorption spectrophotometry. The regional zinc concentrations in other brain regions examined, however, were practically unchanged. Hippocampal zinc levels seemed to decline continuously with time up to 24 h postinjection, when more than 30% reduction was observed. It has been reported earlier that the sulphide silver staining of neuropil regions is reversibly blocked by SDEDTC. Our recent histochemical obervations indicate that this phenomenon is paralleled with a different distribution of hippocampal zinc, e.g. the intensification of Timm's staining of the dentate granule cells and the CA1 pyramidal cells. The perikaryal accumulation of zinc, however, could be prevented by a previous intrahippocampal microinjection of colchicine (20 μg) without influencing the partial depletion of hippocampal zinc content. It is suggested that the SDEDTC treatment induces not ony the partial depletion of chelatable zinc pool from the rat hippocampus, but also the perikaryal accumulation of zinc, which may signify a failure in axonal transport of zinc-binding proteins either anterogradely or retrogradely.

Original languageEnglish
Pages (from-to)287-294
Number of pages8
JournalBrain research
Issue number2
Publication statusPublished - Oct 6 1987


  • Colchicine
  • Depletion
  • Hippocampal zinc
  • Mossy fiber
  • Perikaryal accumulation
  • Rat brain

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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