Partial deafferentiation of the hypothalamic paraventricular nucleus: Effect on the stress or adrenalectomy-induced ACTH secretion

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The role of afferent inputs to the hypothalamic paraventricular nucleus (PVN) from superior, anterior-superior and posterior-superior directions was studied on the ether-stress or adrenalectomy induced ACTH secretion. ACTH peak after ether stress was significantly attenuated in rats bearing superior-posterior lesion, suggesting that afferent inputs to the paraventricular nucleus from posterior direction are essential for the development of ACTH surge driven by stress. Adrenalectomy induced ACTH secretion was not changed after partial PVN deafferentiation which raises the possibility that PVN itself is sensitive to the lack of feedback signal.

Original languageEnglish
Pages (from-to)383-389
Number of pages7
JournalNeuroendocrinology Letters
Issue number5
Publication statusPublished - Jan 1 1990


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Psychiatry and Mental health

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