Parkinson-szindróma és kognitív zavarok.

Translated title of the contribution: Parkinson syndrome and cognitive disorders

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The cognitive (executive) ability of patients with Parkinson's-disease (PD) deteriorates gradually during the progression of the disease. Fluency of speech, word finding, working memory, ability to plan the future and flexibility decline. Cognitive disturbance was found to be proportional with the speech, posture, gait and balance problems and can not be influenced by L-dopa substitution. Apart the dorsal and ventral mesolimbic dopaminergic systems the coerulo-cortical noradrenergic, serotoninergic and cholinergic systems are also impaired in PD. Subcortical dementia in PD can also be explained by the functional disability of dorsolateral and anterior cingular circuits. Attention deficit can be explained by the dopamine depletion of cingular cortex. Cortical Lewy bodies, neurofibrillary tangles, neurit plaques and additional vascular pathology should also play a role in cognitive impairment of PD. In several systemic degenerative diseases associating with Parkinson's syndrome (PS) i.e. progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), multiple system atrophy (MSA) dementia can be detected with various severity, therefore the question arises concerning the correlation between cognitive disability and PS. Parkinson syndrome can also develop in frontotemporal dementias (FTD), Alzheimer's disease and cortical Lewy body disease (CLBD) but no correlation exists between motor disability and severity of dementia. In CLBD dementia can be the initial symptom in 18% of cases but PS can also preceeds the dementia. In PSP profound depletion of other monoaminergic neurotransmitter system was also reported. In FTDs associated with PS degeneration of substantia nigra, locus coeruleus and basal nucleus of Meynert has been reported with increased number of neurofibrillary tangles. In patients with vascular PS (VP) there is generally no tremor and rigidity, but pseudobulbar palsy, dementia, gate disturbance, incontinency appears; L-dopa treatment is generally ineffective. In VP no cellular loss can be found within the substantia nigra, but leukoaraiosis, lacunae in the white matter and basal ganglia are commonly demonstrated.

Original languageHungarian
Pages (from-to)220-225
Number of pages6
JournalIdeggyógyászati szemle
Volume55
Issue number7-8
Publication statusPublished - Jul 20 2002

Fingerprint

Dementia
Lewy Body Disease
Parkinson Disease
Progressive Supranuclear Palsy
Blood Vessels
Neurofibrillary Tangles
Aptitude
Levodopa
Substantia Nigra
Pseudobulbar Palsy
Leukoaraiosis
Basal Nucleus of Meynert
Multiple System Atrophy
Lewy Bodies
Frontotemporal Dementia
Locus Coeruleus
Tremor
Basal Ganglia
Posture
Gait

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Parkinson-szindróma és kognitív zavarok. / Szirmai, I.; Kovács, T.

In: Ideggyógyászati szemle, Vol. 55, No. 7-8, 20.07.2002, p. 220-225.

Research output: Contribution to journalArticle

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