Paraoxonase-1 and myeloperoxidase correlate with vascular biomarkers in overweight patients with newly diagnosed untreated hyperlipidaemia

Anita Szentpéteri, Noémi Zsíros, Viktória E. Varga, Hajnalka Lőrincz, Mónika Katkó, Ildikó Seres, Péter Fülöp, György Paragh, Mariann Harangi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: In hyperlipidaemic state, increased levels of myeloperoxidase (MPO) and decreased paraoxonase-1 (PON1) activity have been reported; however, their relationships with other atherosclerotic biomarkers have not been completely clarified. Patients and methods: Serum concentrations of lipid and inflammatory parameters, MPO levels, and PON1 activities were investigated in 167 untreated hyperlipidaemic patients with and without vascular complications and in 32 healthy controls. Additionally, levels of CD40 ligand (sCD40L) and asymmetric dimethyl arginine (ADMA), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1, and oxidized LDL were determined. Results: We found elevated C-reactive protein (CRP), ADMA, sCD40L, sICAM-1 concentrations, and higher MPO levels in patients with vascular complications compared to those without. The PON1 arylesterase activity correlated negatively with sCD40L, ADMA, and sICAM-1 levels, respectively. In contrast, MPO concentrations showed positive correlations with sCD40L, ADMA, and sICAM-1 levels, respectively. Conclusions: It can therefore be stated that PON1 activity and MPO level correlate strongly with the vascular biomarkers, highlighting the importance of the HDL-associated pro- and antioxidant enzymes in the development of endothelial dysfunction and atherogenesis.

Original languageEnglish
Pages (from-to)370-376
Number of pages7
JournalVasa - European Journal of Vascular Medicine
Volume46
Issue number5
DOIs
Publication statusPublished - Aug 2017

Keywords

  • Asymmetric dimethyl arginine
  • Hyperlipidaemia
  • Myeloperoxidase
  • Paraoxonase
  • SCD40 ligand
  • Soluble intercellular adhesion molecule-1

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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