Paraneoplastic syndrome is a group of clinical symptoms, physical and laboratory abnormalities present in oncologic patients, which can be explained with humoral factors produced by the tumor rather than the mass effect of the primary tumor or its metastases. It occurs in about 10-15% of patients with malignancies. Humoral factors produced by the tumors may substantially modify the symptoms of the primary disease and, not infrequently, the symptoms of an endocrine disorder cause difficulties in the differential diagnosis. In this review the most important diagnostic and therapeutic issues of paraneoplastic acromegaly, ectopic Cushing's and arginin-vasopressin syndromes, paraneoplastic hypercalcemia and osteomalacia, ectopic HCG and renin secretion as well as paraneoplastic hypoglycemia and erythrocytosis are summarized.
|Number of pages||8|
|Journal||Lege Artis Medicinae|
|Publication status||Published - Dec 1 1996|
ASJC Scopus subject areas