Paraneoplastic chronic demyelinating neuropathy and Lambert-Eaton myasthenic syndrome associated with multiple anti-neural antibodies and small-cell lung cancer.

Csilla Rozsa, Angela Vincent, Zsuzsanna Aranyi, Gabor G. Kovacs, Samuel Komoly, Zsolt Illes

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Lambert-Eaton myasthenic syndrome (LEMS) developed in a patient with presumed chronic inflammatory demyelinating polyneuropathy (CIDP) and negative chest CT. Since antibodies against both Hu and voltage-gated calcium channel (VGCC) were detected, repeated chest CT was performed, which eventually showed a pulmonary mass lesion. Biopsy revealed small cell lung cancer (SCLC) indicating the importance of repeated chest CT in LEMS even when an existing autoimmune-like disease and negative CT may suggest an autoimmune origin. This is the first report of paraneoplastic CIDP and LEMS associated with anti-Hu, anti-VGCC and SCLC.

Original languageEnglish
Pages (from-to)325-328
Number of pages4
JournalIdeggyógyászati szemle
Volume61
Issue number9-10
Publication statusPublished - Sep 30 2008

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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