### Abstract

Transpulmonary mechanics of anesthetized intubated dogs were studied during control breathing and hemorrhage-induced hyperventilation by least-mean-squares parameter estimation using several model versions. The classical elastance-resistance model was modified to include nonlinear elastic and viscous pressure terms with and without a linear inertive pressure component. Inclusion of nonlinear terms decreased the root-mean-square error of fitting (q) of the classical model on the average to 67% in the control period and to 58% during hyperventilation. An additional decrease due to inertance was 4% (control) and 22% (hyperventilation) and was associated with acceptable estimates of inertance [0.056 ± 0.02 (SD) and 0.063 ± 0.008 cmH_{2}O.l^{-1}.s, respectively]. When inertance alone was added to the classical model, negligible improvement in q and unrealistic values of inertance were obtained. Conventional measures (Edyn and midvolume resistance) were close to the corresponding least-mean-squares estimates (E and R) of all model versions, except that in hyperventilation neglecting the inertance caused Edyn to markedly overestimate E of the nonlinear inertive model.

Original language | English |
---|---|

Pages (from-to) | 955-963 |

Number of pages | 9 |

Journal | Journal of Applied Physiology Respiratory Environmental and Exercise Physiology |

Volume | 52 |

Issue number | 4 |

Publication status | Published - 1982 |

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### ASJC Scopus subject areas

- Physiology
- Endocrinology

### Cite this

*Journal of Applied Physiology Respiratory Environmental and Exercise Physiology*,

*52*(4), 955-963.

**Parameter estimation of transpulmonary mechanics by a nonlinear inertive method.** / Hantos, Z.; Daroczy, B.; Klebniczki, J.; Dombos, K.; Nagy, S.

Research output: Contribution to journal › Article

*Journal of Applied Physiology Respiratory Environmental and Exercise Physiology*, vol. 52, no. 4, pp. 955-963.

}

TY - JOUR

T1 - Parameter estimation of transpulmonary mechanics by a nonlinear inertive method

AU - Hantos, Z.

AU - Daroczy, B.

AU - Klebniczki, J.

AU - Dombos, K.

AU - Nagy, S.

PY - 1982

Y1 - 1982

N2 - Transpulmonary mechanics of anesthetized intubated dogs were studied during control breathing and hemorrhage-induced hyperventilation by least-mean-squares parameter estimation using several model versions. The classical elastance-resistance model was modified to include nonlinear elastic and viscous pressure terms with and without a linear inertive pressure component. Inclusion of nonlinear terms decreased the root-mean-square error of fitting (q) of the classical model on the average to 67% in the control period and to 58% during hyperventilation. An additional decrease due to inertance was 4% (control) and 22% (hyperventilation) and was associated with acceptable estimates of inertance [0.056 ± 0.02 (SD) and 0.063 ± 0.008 cmH2O.l-1.s, respectively]. When inertance alone was added to the classical model, negligible improvement in q and unrealistic values of inertance were obtained. Conventional measures (Edyn and midvolume resistance) were close to the corresponding least-mean-squares estimates (E and R) of all model versions, except that in hyperventilation neglecting the inertance caused Edyn to markedly overestimate E of the nonlinear inertive model.

AB - Transpulmonary mechanics of anesthetized intubated dogs were studied during control breathing and hemorrhage-induced hyperventilation by least-mean-squares parameter estimation using several model versions. The classical elastance-resistance model was modified to include nonlinear elastic and viscous pressure terms with and without a linear inertive pressure component. Inclusion of nonlinear terms decreased the root-mean-square error of fitting (q) of the classical model on the average to 67% in the control period and to 58% during hyperventilation. An additional decrease due to inertance was 4% (control) and 22% (hyperventilation) and was associated with acceptable estimates of inertance [0.056 ± 0.02 (SD) and 0.063 ± 0.008 cmH2O.l-1.s, respectively]. When inertance alone was added to the classical model, negligible improvement in q and unrealistic values of inertance were obtained. Conventional measures (Edyn and midvolume resistance) were close to the corresponding least-mean-squares estimates (E and R) of all model versions, except that in hyperventilation neglecting the inertance caused Edyn to markedly overestimate E of the nonlinear inertive model.

UR - http://www.scopus.com/inward/record.url?scp=0019988498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019988498&partnerID=8YFLogxK

M3 - Article

C2 - 7085429

AN - SCOPUS:0019988498

VL - 52

SP - 955

EP - 963

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 0161-7567

IS - 4

ER -