### Abstract

Transpulmonary mechanics of anesthetized intubated dogs were studied during control breathing and hemorrhage-induced hyperventilation by least-mean-squares parameter estimation using several model versions. The classical elastance-resistance model was modified to include nonlinear elastic and viscous pressure terms with and without a linear inertive pressure component. Inclusion of nonlinear terms decreased the root-mean-square error of fitting (q) of the classical model on the average to 67% in the control period and to 58% during hyperventilation. An additional decrease due to inertance was 4% (control) and 22% (hyperventilation) and was associated with acceptable estimates of inertance [0.056 ± 0.02 (SD) and 0.063 ± 0.008 cmH_{2}O.l^{-1}.s, respectively]. When inertance alone was added to the classical model, negligible improvement in q and unrealistic values of inertance were obtained. Conventional measures (Edyn and midvolume resistance) were close to the corresponding least-mean-squares estimates (E and R) of all model versions, except that in hyperventilation neglecting the inertance caused Edyn to markedly overestimate E of the nonlinear inertive model.

Original language | English |
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Pages (from-to) | 955-963 |

Number of pages | 9 |

Journal | Journal of Applied Physiology Respiratory Environmental and Exercise Physiology |

Volume | 52 |

Issue number | 4 |

Publication status | Published - Oct 25 1982 |

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### ASJC Scopus subject areas

- Physiology
- Endocrinology

### Cite this

*Journal of Applied Physiology Respiratory Environmental and Exercise Physiology*,

*52*(4), 955-963.