Paradoxical dissociation between gluconeogenic effects and glucocorticoid-receptor binding by gonadal steroids

M. K. Agarwal, G. Lazar, S. Sekiya

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Estradiol and testosterone derivatives both decreased liver glycogen and impaired triamcinolone acetonide mediated gluconeogenesis in male, adrenalectomized fed rats. Neither gonadal steroid influenced binding of either glucocorticoid to its cytoplasmic receptor. Association of 3H-estradiol to liver cytoplasmic binders remained unhampered in presence of one hundredfold excess of either cortisol or triamcinolone.

Original languageEnglish
Pages (from-to)499-504
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume79
Issue number2
DOIs
Publication statusPublished - Nov 21 1977

Fingerprint

Glucocorticoid Receptors
Estradiol
Steroids
Triamcinolone
Triamcinolone Acetonide
Liver Glycogen
Gluconeogenesis
Cytoplasmic and Nuclear Receptors
Liver
Glucocorticoids
Binders
Hydrocortisone
Testosterone
Rats
Derivatives

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Paradoxical dissociation between gluconeogenic effects and glucocorticoid-receptor binding by gonadal steroids. / Agarwal, M. K.; Lazar, G.; Sekiya, S.

In: Biochemical and Biophysical Research Communications, Vol. 79, No. 2, 21.11.1977, p. 499-504.

Research output: Contribution to journalArticle

@article{cc467cfbdb5a4c798bf81dfb6ac47ff8,
title = "Paradoxical dissociation between gluconeogenic effects and glucocorticoid-receptor binding by gonadal steroids",
abstract = "Estradiol and testosterone derivatives both decreased liver glycogen and impaired triamcinolone acetonide mediated gluconeogenesis in male, adrenalectomized fed rats. Neither gonadal steroid influenced binding of either glucocorticoid to its cytoplasmic receptor. Association of 3H-estradiol to liver cytoplasmic binders remained unhampered in presence of one hundredfold excess of either cortisol or triamcinolone.",
author = "Agarwal, {M. K.} and G. Lazar and S. Sekiya",
year = "1977",
month = "11",
day = "21",
doi = "10.1016/0006-291X(77)90185-1",
language = "English",
volume = "79",
pages = "499--504",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Paradoxical dissociation between gluconeogenic effects and glucocorticoid-receptor binding by gonadal steroids

AU - Agarwal, M. K.

AU - Lazar, G.

AU - Sekiya, S.

PY - 1977/11/21

Y1 - 1977/11/21

N2 - Estradiol and testosterone derivatives both decreased liver glycogen and impaired triamcinolone acetonide mediated gluconeogenesis in male, adrenalectomized fed rats. Neither gonadal steroid influenced binding of either glucocorticoid to its cytoplasmic receptor. Association of 3H-estradiol to liver cytoplasmic binders remained unhampered in presence of one hundredfold excess of either cortisol or triamcinolone.

AB - Estradiol and testosterone derivatives both decreased liver glycogen and impaired triamcinolone acetonide mediated gluconeogenesis in male, adrenalectomized fed rats. Neither gonadal steroid influenced binding of either glucocorticoid to its cytoplasmic receptor. Association of 3H-estradiol to liver cytoplasmic binders remained unhampered in presence of one hundredfold excess of either cortisol or triamcinolone.

UR - http://www.scopus.com/inward/record.url?scp=0017699537&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017699537&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(77)90185-1

DO - 10.1016/0006-291X(77)90185-1

M3 - Article

C2 - 22330

AN - SCOPUS:0017699537

VL - 79

SP - 499

EP - 504

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 2

ER -