Paradigms and paradoxes

The conformation of the fundamental unit of hyaluronic acid

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The geometries of the basic dimers of hyaluronan and chondroitin were compared by quantum chemical calculations. As is known the two systems differ in the relative orientation of one hydroxyl group. The basic unit of hyaluronan in its lowest-energy structure is some 20 kJ mol-1 lower in energy than the lowest-energy chondroitin unit. However, the interconversion between the two systems is prevented by a very high energy barrier. The introduction of aqueous medium somewhat changes the relative stabilities of various structures within the hyaluronan sets and chondroitin sets, respectively, but does not change the energy preference of hyaluronan over chondroitin though somewhat diminishes it.

Original languageEnglish
Pages (from-to)1211-1214
Number of pages4
JournalStructural Chemistry
Volume21
Issue number6
DOIs
Publication statusPublished - Dec 2010

Fingerprint

Chondroitin
paradoxes
Hyaluronic Acid
Conformations
acids
energy
Energy barriers
Hydroxyl Radical
Dimers
dimers
Geometry
geometry

Keywords

  • Axial versus equatorial
  • Chondroitin
  • Conformation
  • Hyaluronan
  • Hyaluronic acid

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

Cite this

Paradigms and paradoxes : The conformation of the fundamental unit of hyaluronic acid. / Varga, Z.; Hargittai, I.

In: Structural Chemistry, Vol. 21, No. 6, 12.2010, p. 1211-1214.

Research output: Contribution to journalArticle

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