Paradigmaváltás a daganatok patológiai diagnosztikájában

Molekuláris alapú differenciáldiagnosztika, prognosztikus és prediktív patológia

Translated title of the contribution: Paradigm shift in surgical pathology of cancer: Molecular diagnostics, prognosticators and predictive pathology

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Classical methodology of surgical pathology extended first with ultrastructural methods, then with immunohistochemistry and more recently with molecular/ genomic techniques. These changes added new dimensions to the classical tissueand cellular levels of diagnostics: the molecular level. This change is the primary motor of the development of the diagnostic as well as the prognostic and predictive pathology. It is now possible to identify an ethiological factor (HPV) or reclassify an entire entity (soft tissue tumors). Prognosis of cancer relies more and more on molecular/genetic parameters such as microsatellite instability, gene amplifications etc. Targeted therapy of cancer develops parallel with the molecular predictive pathology such as the anti-HER2 or anti-EGFR therapies. In conclusion, it is fair to say that molecular pathology contributes significantly to the development of clinical oncology.

Original languageHungarian
Pages (from-to)103-112
Number of pages10
JournalMagyar Onkologia
Volume51
Issue number2
Publication statusPublished - 2007

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Surgical Pathology
Molecular Pathology
Pathology
Neoplasms
Microsatellite Instability
Medical Oncology
Gene Amplification
Molecular Biology
Immunohistochemistry
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

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title = "Paradigmav{\'a}lt{\'a}s a daganatok patol{\'o}giai diagnosztik{\'a}j{\'a}ban: Molekul{\'a}ris alap{\'u} differenci{\'a}ldiagnosztika, prognosztikus {\'e}s predikt{\'i}v patol{\'o}gia",
abstract = "Classical methodology of surgical pathology extended first with ultrastructural methods, then with immunohistochemistry and more recently with molecular/ genomic techniques. These changes added new dimensions to the classical tissueand cellular levels of diagnostics: the molecular level. This change is the primary motor of the development of the diagnostic as well as the prognostic and predictive pathology. It is now possible to identify an ethiological factor (HPV) or reclassify an entire entity (soft tissue tumors). Prognosis of cancer relies more and more on molecular/genetic parameters such as microsatellite instability, gene amplifications etc. Targeted therapy of cancer develops parallel with the molecular predictive pathology such as the anti-HER2 or anti-EGFR therapies. In conclusion, it is fair to say that molecular pathology contributes significantly to the development of clinical oncology.",
author = "Zsolt Orosz and Z. S{\'a}pi and Z. Szentirmay and J. T{\'i}m{\'a}r and J. T{\'o}th",
year = "2007",
language = "Hungarian",
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journal = "Magyar Onkologia",
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AU - Orosz, Zsolt

AU - Sápi, Z.

AU - Szentirmay, Z.

AU - Tímár, J.

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AB - Classical methodology of surgical pathology extended first with ultrastructural methods, then with immunohistochemistry and more recently with molecular/ genomic techniques. These changes added new dimensions to the classical tissueand cellular levels of diagnostics: the molecular level. This change is the primary motor of the development of the diagnostic as well as the prognostic and predictive pathology. It is now possible to identify an ethiological factor (HPV) or reclassify an entire entity (soft tissue tumors). Prognosis of cancer relies more and more on molecular/genetic parameters such as microsatellite instability, gene amplifications etc. Targeted therapy of cancer develops parallel with the molecular predictive pathology such as the anti-HER2 or anti-EGFR therapies. In conclusion, it is fair to say that molecular pathology contributes significantly to the development of clinical oncology.

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