Parabrachial origin of calcitonin gene-related peptide-immunoreactive axons innervating Meynert's basal nucleus

Elizabeth Knyihár-Csillik, István Boncz, Gyula Sáry, János Nemcsók, Bertalan Csillik

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Meynert's basal nucleus is innervated by calcitonin gene-related peptide (CGRP)-immunoreactive axons synapsing with cholinergic principal cells. Origin of CGRP-immunopositive axons was studied in the albino rat. Since beaded axons containing the nicotinic acetylcholine receptor (nAChR) are also present in the basal nucleus, the microstructural arrangement raises the question whether or not an interaction between CGRP and nAChR exists like in the neuromuscular junction. We found that electrolytic lesion of the parabrachial nucleus results in degeneration of CGRP-immunoreactive axons in the ipsilateral nucleus basalis and induces shrinkage of principal cholinergic neurons while the contralateral nucleus basalis remains intact. Electrolytic lesions in the thalamus, caudate-putamen, and hippocampus did not induce alterations in Meynert's basal nucleus. Disappearance of CGRP after lesions of the parabrachial nucleus does not impair presynaptic nAChR in the basal nucleus, suggesting that, unlike in the neuromuscular junction, CGRP is not involved in the maintenance of nAChR in the basal forebrain. It is concluded that the parabrachial nucleus is involved in the activation of the nucleus basalis-prefrontal cortex system, essential in gnostic and mnemonic functions.

Original languageEnglish
Pages (from-to)268-276
Number of pages9
JournalExperimental Neurology
Volume157
Issue number2
DOIs
Publication statusPublished - Jun 1999

Fingerprint

Basal Nucleus of Meynert
Calcitonin Gene-Related Peptide
Axons
Nicotinic Receptors
Neuromuscular Junction
Basal Ganglia
Cholinergic Neurons
Putamen
Prefrontal Cortex
Thalamus
Cholinergic Agents
Hippocampus
Maintenance
Parabrachial Nucleus

Keywords

  • Alzheimer's disease
  • Basal nucleus of Meynert
  • Calcitonin gene-related peptide
  • Nicotinic acetylcholine receptor
  • Parabrachial nucleus

ASJC Scopus subject areas

  • Neurology
  • Neuroscience(all)

Cite this

Parabrachial origin of calcitonin gene-related peptide-immunoreactive axons innervating Meynert's basal nucleus. / Knyihár-Csillik, Elizabeth; Boncz, István; Sáry, Gyula; Nemcsók, János; Csillik, Bertalan.

In: Experimental Neurology, Vol. 157, No. 2, 06.1999, p. 268-276.

Research output: Contribution to journalArticle

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