Para substituted amphetamines and brain serotonin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Among the para substituted amphetamines p bromomethamphetamine (V-111) was the most potent inhibitor of synaptosomal reuptake of 3H 5 HT. Both optical isomers of V-111 were equally effective while uptake of 3H NA inhibition and mainly in 3H DA uptake inhibition the (+) form was found to be more potent. Concerning the releasing potency of the former amines, in the case of 3H 5 HT both isomers were equally effective. The release of 3H NA and 3H DA was influenced more effectively by the (+) form. The stereoselective influence of V-111 on the amine reuptake and release suggests a possibility to reach more selective serotonergic and catecholaminergic effects of amphetamines. For the irreversible inhibition of the uptake in vivo presumably one of the metabolites of V-111 is responsible.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalPolish Journal of Pharmacology and Pharmacy
Volume27
Issue numbersup.
Publication statusPublished - 1975

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Amphetamines
Serotonin
Brain
Amines
4-bromomethamphetamine

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Para substituted amphetamines and brain serotonin. / Magyar, K.; Knoll, J.

In: Polish Journal of Pharmacology and Pharmacy, Vol. 27, No. sup., 1975, p. 139-143.

Research output: Contribution to journalArticle

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