Pancreatitis-Associated Genes and Pancreatic Cancer Risk

A Systematic Review and Meta-analysis

Irina Mihaela Cazacu, Nelli Farkas, András Garami, M. Balaskó, Bernadett Mosdósi, Hussain Alizadeh, Zoltán Gyöngyi, Z. Rakonczay, Éva Vigh, Tamás Habon, L. Czopf, Marilena Alina Lazarescu, Bálint Eross, Miklós Sahin-Tóth, P. Hegyi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective The aim of this study was to evaluate the connection between pancreatic cancer (PC) and genetic variants associated with chronic pancreatitis via systematic review and meta-analysis. Methods The data search was performed in 3 major databases (PubMed, Embase, and Cochrane Library). The selected studies have looked into the presence of the pancreatitis-associated genes in patients with PC and in control subjects, the outcome being the frequency of the mutations in the 2 groups. For the binary outcomes, pooled odds ratio (OR) and 95% confidence interval (CI) were calculated. Results Ten articles proved to be eligible for the qualitative synthesis, and 8 articles were suitable for statistical analysis. Six case-control studies, comprising 929 PC cases and 1890 control subjects for serine protease inhibitor Kazal type 1 (SPINK1) mutations, and 5 case-control studies, comprising 1674 PC cases and 19,036 control subjects for CFTR mutations, were enrolled in our analysis. SPINK1 mutations showed no association with PC (OR, 1.52; 95% CI, 0.67-3.45; P = 0.315), whereas mutations in CFTR modestly increased the risk of PC (OR, 1.41; 95% CI, 1.07-1.84; P = 0.013). Conclusion Our meta-analysis showed that mutations in CFTR modestly increase the risk of PC, whereas no association was found between SPINK1 and PC.

Original languageEnglish
Pages (from-to)1078-1086
Number of pages9
JournalPancreas
Volume47
Issue number9
DOIs
Publication statusPublished - Oct 1 2018

Fingerprint

Pancreatic Neoplasms
Pancreatitis
Meta-Analysis
Genes
Serine Proteinase Inhibitors
Mutation
Odds Ratio
Confidence Intervals
Case-Control Studies
Chronic Pancreatitis
Mutation Rate
PubMed
Libraries
Databases

Keywords

  • CFTR
  • chronic pancreatitis
  • pancreatic cancer
  • SPINK1

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Pancreatitis-Associated Genes and Pancreatic Cancer Risk : A Systematic Review and Meta-analysis. / Cazacu, Irina Mihaela; Farkas, Nelli; Garami, András; Balaskó, M.; Mosdósi, Bernadett; Alizadeh, Hussain; Gyöngyi, Zoltán; Rakonczay, Z.; Vigh, Éva; Habon, Tamás; Czopf, L.; Lazarescu, Marilena Alina; Eross, Bálint; Sahin-Tóth, Miklós; Hegyi, P.

In: Pancreas, Vol. 47, No. 9, 01.10.2018, p. 1078-1086.

Research output: Contribution to journalArticle

Cazacu, IM, Farkas, N, Garami, A, Balaskó, M, Mosdósi, B, Alizadeh, H, Gyöngyi, Z, Rakonczay, Z, Vigh, É, Habon, T, Czopf, L, Lazarescu, MA, Eross, B, Sahin-Tóth, M & Hegyi, P 2018, 'Pancreatitis-Associated Genes and Pancreatic Cancer Risk: A Systematic Review and Meta-analysis', Pancreas, vol. 47, no. 9, pp. 1078-1086. https://doi.org/10.1097/MPA.0000000000001145
Cazacu, Irina Mihaela ; Farkas, Nelli ; Garami, András ; Balaskó, M. ; Mosdósi, Bernadett ; Alizadeh, Hussain ; Gyöngyi, Zoltán ; Rakonczay, Z. ; Vigh, Éva ; Habon, Tamás ; Czopf, L. ; Lazarescu, Marilena Alina ; Eross, Bálint ; Sahin-Tóth, Miklós ; Hegyi, P. / Pancreatitis-Associated Genes and Pancreatic Cancer Risk : A Systematic Review and Meta-analysis. In: Pancreas. 2018 ; Vol. 47, No. 9. pp. 1078-1086.
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abstract = "Objective The aim of this study was to evaluate the connection between pancreatic cancer (PC) and genetic variants associated with chronic pancreatitis via systematic review and meta-analysis. Methods The data search was performed in 3 major databases (PubMed, Embase, and Cochrane Library). The selected studies have looked into the presence of the pancreatitis-associated genes in patients with PC and in control subjects, the outcome being the frequency of the mutations in the 2 groups. For the binary outcomes, pooled odds ratio (OR) and 95{\%} confidence interval (CI) were calculated. Results Ten articles proved to be eligible for the qualitative synthesis, and 8 articles were suitable for statistical analysis. Six case-control studies, comprising 929 PC cases and 1890 control subjects for serine protease inhibitor Kazal type 1 (SPINK1) mutations, and 5 case-control studies, comprising 1674 PC cases and 19,036 control subjects for CFTR mutations, were enrolled in our analysis. SPINK1 mutations showed no association with PC (OR, 1.52; 95{\%} CI, 0.67-3.45; P = 0.315), whereas mutations in CFTR modestly increased the risk of PC (OR, 1.41; 95{\%} CI, 1.07-1.84; P = 0.013). Conclusion Our meta-analysis showed that mutations in CFTR modestly increase the risk of PC, whereas no association was found between SPINK1 and PC.",
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AU - Cazacu, Irina Mihaela

AU - Farkas, Nelli

AU - Garami, András

AU - Balaskó, M.

AU - Mosdósi, Bernadett

AU - Alizadeh, Hussain

AU - Gyöngyi, Zoltán

AU - Rakonczay, Z.

AU - Vigh, Éva

AU - Habon, Tamás

AU - Czopf, L.

AU - Lazarescu, Marilena Alina

AU - Eross, Bálint

AU - Sahin-Tóth, Miklós

AU - Hegyi, P.

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N2 - Objective The aim of this study was to evaluate the connection between pancreatic cancer (PC) and genetic variants associated with chronic pancreatitis via systematic review and meta-analysis. Methods The data search was performed in 3 major databases (PubMed, Embase, and Cochrane Library). The selected studies have looked into the presence of the pancreatitis-associated genes in patients with PC and in control subjects, the outcome being the frequency of the mutations in the 2 groups. For the binary outcomes, pooled odds ratio (OR) and 95% confidence interval (CI) were calculated. Results Ten articles proved to be eligible for the qualitative synthesis, and 8 articles were suitable for statistical analysis. Six case-control studies, comprising 929 PC cases and 1890 control subjects for serine protease inhibitor Kazal type 1 (SPINK1) mutations, and 5 case-control studies, comprising 1674 PC cases and 19,036 control subjects for CFTR mutations, were enrolled in our analysis. SPINK1 mutations showed no association with PC (OR, 1.52; 95% CI, 0.67-3.45; P = 0.315), whereas mutations in CFTR modestly increased the risk of PC (OR, 1.41; 95% CI, 1.07-1.84; P = 0.013). Conclusion Our meta-analysis showed that mutations in CFTR modestly increase the risk of PC, whereas no association was found between SPINK1 and PC.

AB - Objective The aim of this study was to evaluate the connection between pancreatic cancer (PC) and genetic variants associated with chronic pancreatitis via systematic review and meta-analysis. Methods The data search was performed in 3 major databases (PubMed, Embase, and Cochrane Library). The selected studies have looked into the presence of the pancreatitis-associated genes in patients with PC and in control subjects, the outcome being the frequency of the mutations in the 2 groups. For the binary outcomes, pooled odds ratio (OR) and 95% confidence interval (CI) were calculated. Results Ten articles proved to be eligible for the qualitative synthesis, and 8 articles were suitable for statistical analysis. Six case-control studies, comprising 929 PC cases and 1890 control subjects for serine protease inhibitor Kazal type 1 (SPINK1) mutations, and 5 case-control studies, comprising 1674 PC cases and 19,036 control subjects for CFTR mutations, were enrolled in our analysis. SPINK1 mutations showed no association with PC (OR, 1.52; 95% CI, 0.67-3.45; P = 0.315), whereas mutations in CFTR modestly increased the risk of PC (OR, 1.41; 95% CI, 1.07-1.84; P = 0.013). Conclusion Our meta-analysis showed that mutations in CFTR modestly increase the risk of PC, whereas no association was found between SPINK1 and PC.

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