Pancreatic trophism in experimental liver cirrhosis

István Nagy, Ferenc Hajnal, Gábor Mohácsi, J. Németh, Zoltán Lászik, A. Pap

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Pancreatic trophism and pancreatic enzyme composition, and plasma levels of cholecystokinin, insulin, glucagon, and glucose in liver cirrhosis induced by chronic thioacetamide administration (0.02% in the drinking water for 12 mo) were studied in rats. Advanced liver cirrhosis was evident in all thioacetamide-treated rats. The weight of the pancreas and its contents of DNA, protein, trypsinogen, chymotrypsinogen, proelastase, secretory trypsin inhibitor, and amylase were significantly increased as compared to the controls. The pancreatic secretory enzyme content changes showed a nonparallelism, characteristic of a cholecystokinin effect. Light and electron microscopy revealed a normal pancreatic architecture. Bioassayed plasma cholecystokinin levels in both fed and 24-h-fasted cirrhotic rats were significantly higher than in the corresponding controls. The plasma glucose, insulin, and glucagon levels demonstrated hypoglycemic tendencies with a glucagon predominance. These findings indicate that advanced liver cirrhosis in the rat is accompanied by pancreatic hypertrophy and hyperplasia, which might be attributed, at least in part, to elevated circulating cholecystokinin levels.

Original languageEnglish
Pages (from-to)157-166
Number of pages10
JournalInternational Journal of Pancreatology
Volume14
Issue number2
DOIs
Publication statusPublished - Oct 1993

Fingerprint

Experimental Liver Cirrhosis
Cholecystokinin
Glucagon
Liver Cirrhosis
Thioacetamide
Chymotrypsinogen
Insulin
Trypsinogen
Glucose
Trypsin Inhibitors
Enzymes
Amylases
Hypoglycemic Agents
Drinking Water
Hypertrophy
Hyperplasia
Pancreas
Electron Microscopy
Light
Weights and Measures

Keywords

  • cholecystokinin
  • glucagon
  • insulin
  • liver cirrhosis
  • pancreas
  • rats
  • Thioacetamide

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Endocrinology

Cite this

Pancreatic trophism in experimental liver cirrhosis. / Nagy, István; Hajnal, Ferenc; Mohácsi, Gábor; Németh, J.; Lászik, Zoltán; Pap, A.

In: International Journal of Pancreatology, Vol. 14, No. 2, 10.1993, p. 157-166.

Research output: Contribution to journalArticle

Nagy, István ; Hajnal, Ferenc ; Mohácsi, Gábor ; Németh, J. ; Lászik, Zoltán ; Pap, A. / Pancreatic trophism in experimental liver cirrhosis. In: International Journal of Pancreatology. 1993 ; Vol. 14, No. 2. pp. 157-166.
@article{230b66b18f9a4715af81b6249a932868,
title = "Pancreatic trophism in experimental liver cirrhosis",
abstract = "Pancreatic trophism and pancreatic enzyme composition, and plasma levels of cholecystokinin, insulin, glucagon, and glucose in liver cirrhosis induced by chronic thioacetamide administration (0.02{\%} in the drinking water for 12 mo) were studied in rats. Advanced liver cirrhosis was evident in all thioacetamide-treated rats. The weight of the pancreas and its contents of DNA, protein, trypsinogen, chymotrypsinogen, proelastase, secretory trypsin inhibitor, and amylase were significantly increased as compared to the controls. The pancreatic secretory enzyme content changes showed a nonparallelism, characteristic of a cholecystokinin effect. Light and electron microscopy revealed a normal pancreatic architecture. Bioassayed plasma cholecystokinin levels in both fed and 24-h-fasted cirrhotic rats were significantly higher than in the corresponding controls. The plasma glucose, insulin, and glucagon levels demonstrated hypoglycemic tendencies with a glucagon predominance. These findings indicate that advanced liver cirrhosis in the rat is accompanied by pancreatic hypertrophy and hyperplasia, which might be attributed, at least in part, to elevated circulating cholecystokinin levels.",
keywords = "cholecystokinin, glucagon, insulin, liver cirrhosis, pancreas, rats, Thioacetamide",
author = "Istv{\'a}n Nagy and Ferenc Hajnal and G{\'a}bor Moh{\'a}csi and J. N{\'e}meth and Zolt{\'a}n L{\'a}szik and A. Pap",
year = "1993",
month = "10",
doi = "10.1007/BF02786122",
language = "English",
volume = "14",
pages = "157--166",
journal = "Journal of Gastrointestinal Cancer",
issn = "1941-6628",
publisher = "Humana Press",
number = "2",

}

TY - JOUR

T1 - Pancreatic trophism in experimental liver cirrhosis

AU - Nagy, István

AU - Hajnal, Ferenc

AU - Mohácsi, Gábor

AU - Németh, J.

AU - Lászik, Zoltán

AU - Pap, A.

PY - 1993/10

Y1 - 1993/10

N2 - Pancreatic trophism and pancreatic enzyme composition, and plasma levels of cholecystokinin, insulin, glucagon, and glucose in liver cirrhosis induced by chronic thioacetamide administration (0.02% in the drinking water for 12 mo) were studied in rats. Advanced liver cirrhosis was evident in all thioacetamide-treated rats. The weight of the pancreas and its contents of DNA, protein, trypsinogen, chymotrypsinogen, proelastase, secretory trypsin inhibitor, and amylase were significantly increased as compared to the controls. The pancreatic secretory enzyme content changes showed a nonparallelism, characteristic of a cholecystokinin effect. Light and electron microscopy revealed a normal pancreatic architecture. Bioassayed plasma cholecystokinin levels in both fed and 24-h-fasted cirrhotic rats were significantly higher than in the corresponding controls. The plasma glucose, insulin, and glucagon levels demonstrated hypoglycemic tendencies with a glucagon predominance. These findings indicate that advanced liver cirrhosis in the rat is accompanied by pancreatic hypertrophy and hyperplasia, which might be attributed, at least in part, to elevated circulating cholecystokinin levels.

AB - Pancreatic trophism and pancreatic enzyme composition, and plasma levels of cholecystokinin, insulin, glucagon, and glucose in liver cirrhosis induced by chronic thioacetamide administration (0.02% in the drinking water for 12 mo) were studied in rats. Advanced liver cirrhosis was evident in all thioacetamide-treated rats. The weight of the pancreas and its contents of DNA, protein, trypsinogen, chymotrypsinogen, proelastase, secretory trypsin inhibitor, and amylase were significantly increased as compared to the controls. The pancreatic secretory enzyme content changes showed a nonparallelism, characteristic of a cholecystokinin effect. Light and electron microscopy revealed a normal pancreatic architecture. Bioassayed plasma cholecystokinin levels in both fed and 24-h-fasted cirrhotic rats were significantly higher than in the corresponding controls. The plasma glucose, insulin, and glucagon levels demonstrated hypoglycemic tendencies with a glucagon predominance. These findings indicate that advanced liver cirrhosis in the rat is accompanied by pancreatic hypertrophy and hyperplasia, which might be attributed, at least in part, to elevated circulating cholecystokinin levels.

KW - cholecystokinin

KW - glucagon

KW - insulin

KW - liver cirrhosis

KW - pancreas

KW - rats

KW - Thioacetamide

UR - http://www.scopus.com/inward/record.url?scp=0027362301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027362301&partnerID=8YFLogxK

U2 - 10.1007/BF02786122

DO - 10.1007/BF02786122

M3 - Article

C2 - 8283079

AN - SCOPUS:0027362301

VL - 14

SP - 157

EP - 166

JO - Journal of Gastrointestinal Cancer

JF - Journal of Gastrointestinal Cancer

SN - 1941-6628

IS - 2

ER -