Pancreatic Polypeptide: A Review

Janos Lonovics, Peter Devitt, Larry C. Watson, Phillip L. Rayford, James C. Thompson

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Pancreatic polypeptide (PP), a 36-amino acid peptide, may function as an important feedback inhibitor of pancreatic secretion after a meal. It arises from both islet and acinar cells of the pancreas. Release of PP by a meal, primarily protein, occurs in a biphasic manner. The first rapid release occurs as a result of vagal stimulation; the second, more prolonged rise (the so-called intestinal phase) occurs in response to hormonal stimulation, predominantly cholecystokinin. Plasma PP levels increase with age; PP levels are elevated above those of age-controlled normal subjects in diabetic patients and in some patients with pancreatic amine precursor uptake decarboxylase tumors. The value of plasma PP as a possible marker for pancreatic tumors is as yet unsettled but may be a valuable tool.

Original languageEnglish
Pages (from-to)1256-1264
Number of pages9
JournalArchives of Surgery
Volume116
Issue number10
DOIs
Publication statusPublished - Oct 1981

ASJC Scopus subject areas

  • Surgery

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    Lonovics, J., Devitt, P., Watson, L. C., Rayford, P. L., & Thompson, J. C. (1981). Pancreatic Polypeptide: A Review. Archives of Surgery, 116(10), 1256-1264. https://doi.org/10.1001/archsurg.1981.01380220010002