Pancreatic cancer

Multicenter prospective data collection and analysis by the hungarian pancreatic study group

Gábor Lakatos, Anita Balázs, Balázs Kui, Szilárd Gódi, Ákos Szücs, Andrea Szentesi, Zsolt Szentkereszty, R. Szmola, Dezső Kelemen, Róbert Papp, A. Vincze, József Czimmer, G. Pár, Judit Bajor, Imre Szabó, F. Izbéki, Adrienn Halász, László Leindler, Gyula Farkas, T. Takács & 4 others L. Czakó, Zoltán Szepes, P. Hegyi, Z. Kahán

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background & Aims: Pancreatic cancer is a devastating disease with poor prognosis. There is very limited information available regarding the epidemiology and treatment strategies of pancreatic cancer in Central Europe. The purpose of the study was to prospectively collect and analyze data of pancreatic cancer in the Hungarian population. Methods: The Hungarian Pancreatic Study Group (HPSG) organized prospective, uniform data collection. Altogether 354 patients were enrolled from 14 Hungarian centers. Results: Chronic pancreatitis was present in 3.7% of the cases, while 33.7% of the patients had diabetes. Family history for pancreatic cancer was positive in 4.8%. The most frequent presenting symptoms included pain (63.8%), weight loss (63%) and jaundice (52.5%). The reported frequency of smoking and alcohol consumption was lower than expected (28.5% and 27.4%, respectively). The majority of patients (75.6%) were diagnosed with advanced disease. Most patients (83.6%) had a primary tumor located in the pancreatic head. The histological diagnosis was ductal adenocarcinoma in 90.7% of the cases, while neuroendocrine tumor was present in 5.3%. Biliary stent implantation was performed in 166 patients, 59.2% of them received metal stents. Primary tumor resection was performed in 60 (16.9%) patients. Enteral or biliary bypass was done in 35 and 49 patients, respectively. In a multivariate Cox-regression model, smoking status and presence of gemcitabine-based chemotherapy were identified as independent predictors for overall survival. Conclusion: We report the first data from a large cohort of Hungarian pancreatic cancer patients. We identified smoking status and chemotherapy as independent predictors in this cohort.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalJournal of gastrointestinal and liver diseases : JGLD
Volume25
Issue number2
Publication statusPublished - Jun 1 2016

Fingerprint

Pancreatic Neoplasms
Smoking
gemcitabine
Stents
Drug Therapy
Neuroendocrine Tumors
Chronic Pancreatitis
Jaundice
Proportional Hazards Models
Alcohol Drinking
Small Intestine
Weight Loss
Neoplasms
Epidemiology
Adenocarcinoma
Metals
Pain
Survival
Population

Keywords

  • Acute pancreatitis
  • Chronic pancreatitis
  • Diabetes mellitus
  • Hungarian cohort
  • Pancreatic cancer

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Pancreatic cancer : Multicenter prospective data collection and analysis by the hungarian pancreatic study group. / Lakatos, Gábor; Balázs, Anita; Kui, Balázs; Gódi, Szilárd; Szücs, Ákos; Szentesi, Andrea; Szentkereszty, Zsolt; Szmola, R.; Kelemen, Dezső; Papp, Róbert; Vincze, A.; Czimmer, József; Pár, G.; Bajor, Judit; Szabó, Imre; Izbéki, F.; Halász, Adrienn; Leindler, László; Farkas, Gyula; Takács, T.; Czakó, L.; Szepes, Zoltán; Hegyi, P.; Kahán, Z.

In: Journal of gastrointestinal and liver diseases : JGLD, Vol. 25, No. 2, 01.06.2016, p. 219-225.

Research output: Contribution to journalArticle

Lakatos, G, Balázs, A, Kui, B, Gódi, S, Szücs, Á, Szentesi, A, Szentkereszty, Z, Szmola, R, Kelemen, D, Papp, R, Vincze, A, Czimmer, J, Pár, G, Bajor, J, Szabó, I, Izbéki, F, Halász, A, Leindler, L, Farkas, G, Takács, T, Czakó, L, Szepes, Z, Hegyi, P & Kahán, Z 2016, 'Pancreatic cancer: Multicenter prospective data collection and analysis by the hungarian pancreatic study group', Journal of gastrointestinal and liver diseases : JGLD, vol. 25, no. 2, pp. 219-225.
Lakatos, Gábor ; Balázs, Anita ; Kui, Balázs ; Gódi, Szilárd ; Szücs, Ákos ; Szentesi, Andrea ; Szentkereszty, Zsolt ; Szmola, R. ; Kelemen, Dezső ; Papp, Róbert ; Vincze, A. ; Czimmer, József ; Pár, G. ; Bajor, Judit ; Szabó, Imre ; Izbéki, F. ; Halász, Adrienn ; Leindler, László ; Farkas, Gyula ; Takács, T. ; Czakó, L. ; Szepes, Zoltán ; Hegyi, P. ; Kahán, Z. / Pancreatic cancer : Multicenter prospective data collection and analysis by the hungarian pancreatic study group. In: Journal of gastrointestinal and liver diseases : JGLD. 2016 ; Vol. 25, No. 2. pp. 219-225.
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AU - Lakatos, Gábor

AU - Balázs, Anita

AU - Kui, Balázs

AU - Gódi, Szilárd

AU - Szücs, Ákos

AU - Szentesi, Andrea

AU - Szentkereszty, Zsolt

AU - Szmola, R.

AU - Kelemen, Dezső

AU - Papp, Róbert

AU - Vincze, A.

AU - Czimmer, József

AU - Pár, G.

AU - Bajor, Judit

AU - Szabó, Imre

AU - Izbéki, F.

AU - Halász, Adrienn

AU - Leindler, László

AU - Farkas, Gyula

AU - Takács, T.

AU - Czakó, L.

AU - Szepes, Zoltán

AU - Hegyi, P.

AU - Kahán, Z.

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