Palmityl-coenzyme a inhibition of the citrate-condensing enzyme

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Abstract

The citrate-condensing enzyme (citrate oxaloacetate-lyase (CoA-acetylating), EC 4.1.3.7) can be partially protected from palmityl-CoA inhibition by oxaloacetate. The interaction between the enzyme and palmityl-CoA led to the firm binding of about 16 moles of the compound per mole of enzyme for a 27% inhibited enzyme. With a 70% inhibited enzyme little change was seen in the sedimentation behavior. On the basis of relationships already reported between palmityl-CoA levels and citrate levels in tissues it is suggested that the interaction is not physiologically significant.

Original languageEnglish
Pages (from-to)445-455
Number of pages11
JournalBiochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume106
Issue number3
Publication statusPublished - Dec 2 1965

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Coenzymes
Citric Acid
Palmitoyl Coenzyme A
Enzymes
Oxaloacetic Acid
citrate (pro-3S)-lyase
Lyases
Coenzyme A
Sedimentation
Tissue

ASJC Scopus subject areas

  • Endocrinology
  • Biophysics
  • Biochemistry
  • Medicine(all)

Cite this

Palmityl-coenzyme a inhibition of the citrate-condensing enzyme. / Srere, P.

In: Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism, Vol. 106, No. 3, 02.12.1965, p. 445-455.

Research output: Contribution to journalArticle

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