Palladium-catalyzed Sonogashira coupling reactions in γ-valerolactone-based ionic liquids

László Orha, József M. Tukacs, László Kollár, László T. Mika

Research output: Contribution to journalArticle

Abstract

It was demonstrated that the γ-valerolactone-based ionic liquid, tetrabutylphosphonium 4-ethoxyvalerate as a partially bio-based solvent can be utilized as alternative reaction medium for copper- and auxiliary base-free Pd-catalyzed Sonogashira coupling reactions of aryl iodides and functionalized acetylenes under mild conditions. Twenty-two cross-coupling products were isolated with good to excellent yields (72–99%) and purity (>98%). These results represent an example which proves that biomass-derived safer solvents can be utilized efficiently in common, industrially important transformations exhibiting higher chemical and environmental efficiency.

Original languageEnglish
Pages (from-to)2907-2913
Number of pages7
JournalBeilstein Journal of Organic Chemistry
Volume15
DOIs
Publication statusPublished - Dec 3 2019

Keywords

  • Catalysis
  • Cross coupling
  • Green chemistry
  • Ionic liquids

ASJC Scopus subject areas

  • Organic Chemistry

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