Palladium-catalyzed arylation of α-methylene-γ-butyrolactone: 3-benzylfuran-2(5H)-ones vs (Z)-benzylidene-γ-butyrolactones and their reduction to 3-benzyl-γ-butyrolactones

Antonio Arcadi, Marco Chiarini, Fabio Marinelli, Zoltán Berente, Làszlò Kollàr

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

(formula presented) The palladium-catalyzed arylation of the α-methylene-γ-butyrolactone proceeds in good yields and may be directed toward the synthesis of 3-benzylfuran-2(5H)-ones when the starting aryl iodides contain strongly electron-withdrawing groups. The combined palladium-catalyzed arylation/hydrogenation of the α-methylene-γ-butyrolactone represents a new simple entry into functionalized α-benzyl-γ-butyrolactones.

Original languageEnglish
Pages (from-to)69-72
Number of pages4
JournalOrganic Letters
Volume2
Issue number1
DOIs
Publication statusPublished - Jan 2000

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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