Palladium-Catalysed Sonogashira Reactions of 16-(Hydroxymethylidene)-3-methoxy-α-estrone

Stefan Jopp, Marko Liesegang, Peter Ehlers, E. Frank, G. Schneider, J. Wölfling, Alexander Villinger, Peter Langer

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Sonogashira reactions of steroids have been studied. The reaction of α-estron-16-methylidenyloxy triflate with various alkynes afforded novel alkynylvinylidene steroids. The reactions proceeded in good to quantitative yields, with excellent E -selectivity and with a broad synthetic scope.

Original languageEnglish
Pages (from-to)2647-2649
Number of pages3
JournalSynlett
Volume28
Issue number19
DOIs
Publication statusPublished - Dec 1 2017

Fingerprint

Estrone
Palladium
Steroids
Alkynes

Keywords

  • alkynes
  • estrone
  • palladium
  • Sonogashira coupling
  • steroids

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Palladium-Catalysed Sonogashira Reactions of 16-(Hydroxymethylidene)-3-methoxy-α-estrone. / Jopp, Stefan; Liesegang, Marko; Ehlers, Peter; Frank, E.; Schneider, G.; Wölfling, J.; Villinger, Alexander; Langer, Peter.

In: Synlett, Vol. 28, No. 19, 01.12.2017, p. 2647-2649.

Research output: Contribution to journalArticle

Jopp, Stefan ; Liesegang, Marko ; Ehlers, Peter ; Frank, E. ; Schneider, G. ; Wölfling, J. ; Villinger, Alexander ; Langer, Peter. / Palladium-Catalysed Sonogashira Reactions of 16-(Hydroxymethylidene)-3-methoxy-α-estrone. In: Synlett. 2017 ; Vol. 28, No. 19. pp. 2647-2649.
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