Palladium-catalysed aminocarbonylation of diiodopyridines

Attila Takács, Georgina Márta Varga, Johanna Kardos, L. Kollár

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The aminocarbonylation of 2,5- and 2,3-diiodopyridine, as well as 2-chloro-3,4-diiodopyridine with carbon monoxide and various primary and secondary amines was carried out using palladium-catalysed aminocarbonylation. The formation of the products containing carboxamide and ketocarboxamide functionalities was accompanied by the formation of imides when ortho-diiodo compounds were used as substrates. In spite of several possible reaction pathways, most of the products were synthesised as major product in yields of synthetic interest by the appropriate modification of the reaction conditions.

Original languageEnglish
Pages (from-to)2131-2138
Number of pages8
JournalTetrahedron
Volume73
Issue number15
DOIs
Publication statusPublished - Apr 13 2017

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Imides
Palladium
Carbon Monoxide
Amines
Substrates

Keywords

  • Carbon monoxide
  • Carbonylation
  • Cycloaminocarbonylation
  • Diiodopyridine
  • Palladium

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Palladium-catalysed aminocarbonylation of diiodopyridines. / Takács, Attila; Varga, Georgina Márta; Kardos, Johanna; Kollár, L.

In: Tetrahedron, Vol. 73, No. 15, 13.04.2017, p. 2131-2138.

Research output: Contribution to journalArticle

Takács, Attila ; Varga, Georgina Márta ; Kardos, Johanna ; Kollár, L. / Palladium-catalysed aminocarbonylation of diiodopyridines. In: Tetrahedron. 2017 ; Vol. 73, No. 15. pp. 2131-2138.
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