PACAP38 and PACAP27 administered intracerebroventricularly have an opposite effect on LH secretion

O. Kántor, J. Molnár, A. Arimura, K. Köves

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The effect of PACAP38 on the LH surge and ovulation was compared with that of PACAP27 and VIP in the same model. The peptides were administered intracerebroventricularly before the critical period of the proestrous stage. PACAP38 was able to inhibit ovulation and to prevent the preovulatory LH surge; however, PACAP27 did not inhibit the ovulation and VIP inhibited the ovulation in 2/11 animals. In those animals of the last two groups in which ovulation occurred, the preovulatory LH surge was higher than in control rats. It is speculated that the opposite effect of PACAP38 and PACAP27 on the preovulatory LH surge and ovulation is possibly mediated through different receptors. (C) 2000 Elsevier Science Inc.

Original languageEnglish
Pages (from-to)817-820
Number of pages4
JournalPeptides
Volume21
Issue number6
DOIs
Publication statusPublished - Jun 2000

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Pituitary Adenylate Cyclase-Activating Polypeptide
Ovulation
Animals
Rat control
Peptides

Keywords

  • LH
  • Ovulation
  • PACAP27
  • PACAP38
  • Rat
  • VIP

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

PACAP38 and PACAP27 administered intracerebroventricularly have an opposite effect on LH secretion. / Kántor, O.; Molnár, J.; Arimura, A.; Köves, K.

In: Peptides, Vol. 21, No. 6, 06.2000, p. 817-820.

Research output: Contribution to journalArticle

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