PACAP inhibits oxidative stress-induced activation of MAP kinase-dependent apoptotic pathway in cultured cardiomyocytes

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16 Citations (Scopus)

Abstract

The present article investigated the effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on oxidative stress-induced apoptosis in neonatal rat cardiomyocytes. Our results show that PACAP decreased the ratio of apoptotic cells following H2O2 treatment. PACAP also diminished the activity of apoptosis signal-regulating kinase. These effects of PACAP were counteracted by the PACAP antagonist PACAP6-38. In summary, our results show that PACAP is able to attenuate oxidative stress-induced cardiomyocyte apoptosis and suggest that its cardioprotective effect is mediated through inhibition of the MAP kinase-dependent apoptotic pathway.

Original languageEnglish
Pages (from-to)293-297
Number of pages5
JournalAnnals of the New York Academy of Sciences
Volume1070
DOIs
Publication statusPublished - Jul 2006

Fingerprint

Pituitary Adenylate Cyclase-Activating Polypeptide
Oxidative stress
Cardiac Myocytes
Oxidative Stress
Phosphotransferases
Chemical activation
Apoptosis
Pathway
Activation
Rats
Cells

Keywords

  • Apoptosis
  • Apoptosis signal-regulating kinase
  • Cardiomyocyte
  • PACAP

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "PACAP inhibits oxidative stress-induced activation of MAP kinase-dependent apoptotic pathway in cultured cardiomyocytes",
abstract = "The present article investigated the effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on oxidative stress-induced apoptosis in neonatal rat cardiomyocytes. Our results show that PACAP decreased the ratio of apoptotic cells following H2O2 treatment. PACAP also diminished the activity of apoptosis signal-regulating kinase. These effects of PACAP were counteracted by the PACAP antagonist PACAP6-38. In summary, our results show that PACAP is able to attenuate oxidative stress-induced cardiomyocyte apoptosis and suggest that its cardioprotective effect is mediated through inhibition of the MAP kinase-dependent apoptotic pathway.",
keywords = "Apoptosis, Apoptosis signal-regulating kinase, Cardiomyocyte, PACAP",
author = "B. Gasz and B. R{\'a}cz and E. Rőth and B. Borsiczky and A. Tam{\'a}s and A. Boronkai and F. Gallyas and G. T{\'o}th and D. Reglodi",
year = "2006",
month = "7",
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language = "English",
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pages = "293--297",
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TY - JOUR

T1 - PACAP inhibits oxidative stress-induced activation of MAP kinase-dependent apoptotic pathway in cultured cardiomyocytes

AU - Gasz, B.

AU - Rácz, B.

AU - Rőth, E.

AU - Borsiczky, B.

AU - Tamás, A.

AU - Boronkai, A.

AU - Gallyas, F.

AU - Tóth, G.

AU - Reglodi, D.

PY - 2006/7

Y1 - 2006/7

N2 - The present article investigated the effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on oxidative stress-induced apoptosis in neonatal rat cardiomyocytes. Our results show that PACAP decreased the ratio of apoptotic cells following H2O2 treatment. PACAP also diminished the activity of apoptosis signal-regulating kinase. These effects of PACAP were counteracted by the PACAP antagonist PACAP6-38. In summary, our results show that PACAP is able to attenuate oxidative stress-induced cardiomyocyte apoptosis and suggest that its cardioprotective effect is mediated through inhibition of the MAP kinase-dependent apoptotic pathway.

AB - The present article investigated the effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on oxidative stress-induced apoptosis in neonatal rat cardiomyocytes. Our results show that PACAP decreased the ratio of apoptotic cells following H2O2 treatment. PACAP also diminished the activity of apoptosis signal-regulating kinase. These effects of PACAP were counteracted by the PACAP antagonist PACAP6-38. In summary, our results show that PACAP is able to attenuate oxidative stress-induced cardiomyocyte apoptosis and suggest that its cardioprotective effect is mediated through inhibition of the MAP kinase-dependent apoptotic pathway.

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KW - Apoptosis signal-regulating kinase

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