PACAP colocalizes with luteinizing and follicle-stimulating hormone immunoreactivities in the anterior lobe of the pituitary gland

Katalin Köves, Orsolya Kántor, Johnatan G. Scammell, Akira Arimura

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Pituitary adenylate cyclase activating polypeptide (PACAP) and its close relative vasoactive intestinal polypeptide (VIP) were demonstrated in the anterior pituitary gland. The cells which exhibited PACAP immunoreactivity were oval or round shaped. Their distribution was similar to that of gonadotropes but the number of PACAP immunoreactive cells was less. Double labeling revealed that PACAP immunoreactivity partially colocalized with luteinizing and follicle-stimulating hormone; however, colocalization with other pituitary hormone immunoreactivities was not demonstrated. Our results suggest an autocrine or paracrine role of PACAP in the regulation of pituitary functions.

Original languageEnglish
Pages (from-to)1069-1072
Number of pages4
JournalPeptides
Volume19
Issue number6
DOIs
Publication statusPublished - Jun 1 1998

Keywords

  • Anterior pituitary
  • Double labeling
  • Follicle-stimulating hormone
  • Immunohistochemistry
  • Luteinizing hormone
  • PACAP
  • Rat

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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