p53 in malignant and benign liver lesions

Z. Schaff, I. Sárosi, C. C. Hsia, A. Kiss, E. Tabor

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

p53 expression was studied by immunohistochemical methods in benign and malignant human epithelial liver lesions in 46 patients from Hungary. Positive immunostaining for p53 protein, indicating the overexpression or prolonged half-life of p53 protein, was detected in the nuclei of tumour cells of seven of the 16 hepatocellular carcinomas (HCC) (44%), including three HCC patients with hepatitis B virus infection. Immunostaining of p53 was seen in one of the seven hepatoblastomas, none of the 17 focal nodular hyperplasias, and none of the six hepatocellular adenomas. The detection of p53 in a relatively high percentage of the HCC cases in Hungary, a country in which aflatoxin contamination of the diet is rare, suggests that factors other than aflatoxin led to the accumulation or overexpression of p53 in these patients.

Original languageEnglish
Pages (from-to)1847-1850
Number of pages4
JournalEuropean Journal of Cancer
Volume31
Issue number11
DOIs
Publication statusPublished - 1995

Fingerprint

Hepatocellular Carcinoma
Aflatoxins
Hungary
Liver
Liver Cell Adenoma
Focal Nodular Hyperplasia
Hepatoblastoma
Virus Diseases
Cell Nucleus
Hepatitis B virus
Half-Life
Proteins
Diet
Neoplasms

Keywords

  • benign liver lesions
  • hepatoblastoma
  • hepatocellular carcinoma
  • immunohistochemistry
  • p53

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Hematology

Cite this

Schaff, Z., Sárosi, I., Hsia, C. C., Kiss, A., & Tabor, E. (1995). p53 in malignant and benign liver lesions. European Journal of Cancer, 31(11), 1847-1850. https://doi.org/10.1016/0959-8049(95)00380-2

p53 in malignant and benign liver lesions. / Schaff, Z.; Sárosi, I.; Hsia, C. C.; Kiss, A.; Tabor, E.

In: European Journal of Cancer, Vol. 31, No. 11, 1995, p. 1847-1850.

Research output: Contribution to journalArticle

Schaff, Z, Sárosi, I, Hsia, CC, Kiss, A & Tabor, E 1995, 'p53 in malignant and benign liver lesions', European Journal of Cancer, vol. 31, no. 11, pp. 1847-1850. https://doi.org/10.1016/0959-8049(95)00380-2
Schaff, Z. ; Sárosi, I. ; Hsia, C. C. ; Kiss, A. ; Tabor, E. / p53 in malignant and benign liver lesions. In: European Journal of Cancer. 1995 ; Vol. 31, No. 11. pp. 1847-1850.
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