P2X7 receptors in the nervous system

B. Sperlágh, E. Vízi, Kerstin Wirkner, Peter Illes

Research output: Contribution to journalArticle

283 Citations (Scopus)

Abstract

P2X7 receptors are ligand-gated ion channels, expressed as homo-oligomeric assemblies of individual subunits. They are widely distributed at immunocompetent cells of the central and peripheral nervous system and are believed to be primarily involved in host-defense reaction. However, a growing amount of evidence indicates that their signaling role in the brain is more widespread than previously anticipated. In this paper, we review the present knowledge on the structural and pharmacological features of the P2X7 receptor, as well as its cell-type specific localization in the nervous system. Subsequently, the participation of P2X7 receptors in distinct neuronal, astroglial and microglial functions are described. Finally, since they may play a prominent role in certain neurologic disorders, such as ischemia-reperfusion injury, Alzheimer's disease, spinal cord injury and sensory neuropathies, the pathological role and potential therapeutic exploitation of P2X7 receptors are also discussed.

Original languageEnglish
Pages (from-to)327-346
Number of pages20
JournalProgress in Neurobiology
Volume78
Issue number6
DOIs
Publication statusPublished - Apr 2006

Fingerprint

Purinergic P2X7 Receptors
Nervous System
Ligand-Gated Ion Channels
Peripheral Nervous System
Nervous System Diseases
Reperfusion Injury
Spinal Cord Injuries
Alzheimer Disease
Central Nervous System
Pharmacology
Brain

Keywords

  • Astrocyte
  • ATP
  • Microglia
  • Neuron
  • P2X receptor
  • Presynaptic

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

P2X7 receptors in the nervous system. / Sperlágh, B.; Vízi, E.; Wirkner, Kerstin; Illes, Peter.

In: Progress in Neurobiology, Vol. 78, No. 6, 04.2006, p. 327-346.

Research output: Contribution to journalArticle

Sperlágh, B. ; Vízi, E. ; Wirkner, Kerstin ; Illes, Peter. / P2X7 receptors in the nervous system. In: Progress in Neurobiology. 2006 ; Vol. 78, No. 6. pp. 327-346.
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