P2X3 receptor involvement in pain states

Kerstin Wirkner, B. Sperlágh, Peter Illes

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

The understanding of how pain is processed at each stage in the peripheral and central nervous system is the precondition to develop new therapies for the selective treatment of pain. In the periphery, ATP can be released from various cells as a consequence of tissue injury or visceral distension and may stimulate the local nociceptors. The highly selective distribution of P2X3 and P2X2/3 receptors within the nociceptive system has inspired a variety of approaches to elucidate the potential role of ATP as a pain mediator. Depolarization by ATP of neurons in pain-relevant neuronal structures such as trigeminal ganglion, dorsal root ganglion, and spinal cord dorsal horn neurons are well investigated. P2X receptor-mediated afferent activation appears to have been implicated in visceral and neuropathic pain and even in migraine and cancer pain. This article reviews recently published research describing the role that ATP and P2X receptors may play in pain perception, highlighting the importance of the P2X3 receptor in different states of pain.

Original languageEnglish
Pages (from-to)165-183
Number of pages19
JournalMolecular Neurobiology
Volume36
Issue number2
DOIs
Publication statusPublished - Oct 2007

Fingerprint

Purinergic P2X3 Receptors
Pain
Adenosine Triphosphate
Purinergic P2X2 Receptors
Visceral Pain
Purinergic P2 Receptors
Posterior Horn Cells
Trigeminal Ganglion
Nociceptors
Pain Perception
Peripheral Nervous System
Spinal Ganglia
Neuralgia
Migraine Disorders
Central Nervous System
Neurons
Wounds and Injuries
Therapeutics
Research

Keywords

  • Acute pain
  • Inflammation
  • Neurophatic pain
  • P2X receptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Cite this

P2X3 receptor involvement in pain states. / Wirkner, Kerstin; Sperlágh, B.; Illes, Peter.

In: Molecular Neurobiology, Vol. 36, No. 2, 10.2007, p. 165-183.

Research output: Contribution to journalArticle

Wirkner, Kerstin ; Sperlágh, B. ; Illes, Peter. / P2X3 receptor involvement in pain states. In: Molecular Neurobiology. 2007 ; Vol. 36, No. 2. pp. 165-183.
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