P2X4 receptors, immunity, and sepsis

Luca Antonioli, Corrado Blandizzi, Matteo Fornai, Pál Pacher, H. Thomas Lee, G. Haskó

Research output: Contribution to journalReview article

Abstract

Sepsis is life-threatening systemic organ dysfunction caused by a deregulated host response to an infectious insult. Currently, the treatment of sepsis is limited to the use of antibiotics, fluids, and cardiovascular/respiratory support. Despite these interventions, septic mortality remains high, with reduced life quality in survivors. For this reason, the identification of novel drug targets is a pressing task of modern pharmacology. According to a recent research, it appears that P2 purinergic receptors, which can regulate the host's response to infections, have been identified as potential targets for the treatment of sepsis. Among P2 receptors, the P2X 4 receptor has recently captured the attention of the research community owing to its role in protecting against infections, inflammation, and organ injury. The present review provides an outline of the role played by P2X 4 receptors in the modulation of the host's response to sepsis and the promise that targeting this receptor holds in the treatment of sepsis.

Original languageEnglish
Pages (from-to)65-74
Number of pages10
JournalCurrent Opinion in Pharmacology
Volume47
DOIs
Publication statusPublished - Aug 1 2019

Fingerprint

Purinergic P2X4 Receptors
Immunity
Sepsis
Purinergic P2 Receptors
Infection
Research
Survivors
Therapeutics
Quality of Life
Pharmacology
Anti-Bacterial Agents
Inflammation
Mortality
Wounds and Injuries
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Antonioli, L., Blandizzi, C., Fornai, M., Pacher, P., Lee, H. T., & Haskó, G. (2019). P2X4 receptors, immunity, and sepsis. Current Opinion in Pharmacology, 47, 65-74. https://doi.org/10.1016/j.coph.2019.02.011

P2X4 receptors, immunity, and sepsis. / Antonioli, Luca; Blandizzi, Corrado; Fornai, Matteo; Pacher, Pál; Lee, H. Thomas; Haskó, G.

In: Current Opinion in Pharmacology, Vol. 47, 01.08.2019, p. 65-74.

Research output: Contribution to journalReview article

Antonioli, L, Blandizzi, C, Fornai, M, Pacher, P, Lee, HT & Haskó, G 2019, 'P2X4 receptors, immunity, and sepsis', Current Opinion in Pharmacology, vol. 47, pp. 65-74. https://doi.org/10.1016/j.coph.2019.02.011
Antonioli, Luca ; Blandizzi, Corrado ; Fornai, Matteo ; Pacher, Pál ; Lee, H. Thomas ; Haskó, G. / P2X4 receptors, immunity, and sepsis. In: Current Opinion in Pharmacology. 2019 ; Vol. 47. pp. 65-74.
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