P2 receptor-mediated modulation of neurotransmitter release - An update

B. Sperlágh, Attila Heinrich, Cecilia Csöllle

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Presynaptic nerve terminals are equipped with a number of presynaptic auto- and heteroreceptors, including ionotropic P2X and metabotropic P2Y receptors. P2 receptors serve as modulation sites of transmitter release by ATP and other nucleotides released by neuronal activity and pathological signals. A wide variety of P2X and P2Y receptors expressed at pre- and postsynaptic sites as well as in glial cells are involved directly or indirectly in the modulation of neurotransmitter release. Nucleotides are released from synaptic and nonsynaptic sites throughout the nervous system and might reach concentrations high enough to activate these receptors. By providing a fine-tuning mechanism these receptors also offer attractive sites for pharmacotherapy in nervous system diseases. Here we review the rapidly emerging data on the modulation of transmitter release by facilitatory and inhibitory P2 receptors and the receptor subtypes involved in these interactions.

Original languageEnglish
Pages (from-to)269-284
Number of pages16
JournalPurinergic Signalling
Volume3
Issue number4
DOIs
Publication statusPublished - Sep 2007

Fingerprint

Neurotransmitter Agents
Nucleotides
Autoreceptors
Presynaptic Terminals
Nervous System Diseases
Neuroglia
Nervous System
Adenosine Triphosphate
Drug Therapy

Keywords

  • Neuromodulation
  • P2X receptor
  • P2Y receptors
  • Presynaptic
  • Release
  • Transmitter

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine
  • Cellular and Molecular Neuroscience

Cite this

P2 receptor-mediated modulation of neurotransmitter release - An update. / Sperlágh, B.; Heinrich, Attila; Csöllle, Cecilia.

In: Purinergic Signalling, Vol. 3, No. 4, 09.2007, p. 269-284.

Research output: Contribution to journalArticle

Sperlágh, B. ; Heinrich, Attila ; Csöllle, Cecilia. / P2 receptor-mediated modulation of neurotransmitter release - An update. In: Purinergic Signalling. 2007 ; Vol. 3, No. 4. pp. 269-284.
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