P-ligand-free, microwave-assisted variation of the Hirao reaction under solvent-free conditions; The P-C coupling reaction of >p(O)H species and bromoarenes

Erzsébet Jablonkai, György Keglevich

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Under microwave conditions, the P-C coupling of aryl bromides and >P(O)H species, such as dialkyl phosphites, alkyl aryl-H-phosphinates, or diphenylphosphine oxide takes place in the presence of Pd(OAc)2 as the catalyst and triethylamine as the base without using any P-ligand or solvent. The method described is green and is of more general value.

Original languageEnglish
Pages (from-to)4185-4188
Number of pages4
JournalTetrahedron Letters
Volume54
Issue number32
DOIs
Publication statusPublished - Aug 7 2013

Keywords

  • Aryl phosphonate
  • Dialkyl phosphate
  • Hirao reaction
  • Microwave
  • P-C coupling
  • P-ligand-free

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Fingerprint Dive into the research topics of 'P-ligand-free, microwave-assisted variation of the Hirao reaction under solvent-free conditions; The P-C coupling reaction of >p(O)H species and bromoarenes'. Together they form a unique fingerprint.

  • Cite this