P-170 glycoprotein, glutathione and associated enzymes in relation to chemoresistance of primary human renal cell carcinomas

Gerald H. Mickisch, H. Bier, W. Bergler, M. Bak, R. Tschada, P. Aiken

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

High intrinsic chemoresistance contributes to the dismal outcome of patients with disseminated renal cell carcinoma (RCC). In experimental cell lines, two defined defence mechanisms, P-170 glycoprotein and glutathione metabolism, have been established in multidrug resistance, a cross-resistance to cytotoxic compounds without functional or structural similarities. In 21 primary human RCCs, P-170 expression was examined, glutathione content and activities of related enzymes determined and the results were correlated to the degree of in vitro chemoresistance. P-170 was found in 10 of 17 resistant tumors but in none of the sensitive cases. The glutathione content was significantly higher and the related enzyme distinctively enhanced in resistant RCCs. Both mechanisms occurred independently and may well explain the multidrug resistance of RCC. Therefore, reversal of one or both systems may have a clinical impact on the chemotherapy of RCCs.

Original languageEnglish
Pages (from-to)170-176
Number of pages7
JournalUrologia Internationalis
Volume45
Issue number3
DOIs
Publication statusPublished - 1990

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P-Glycoprotein
Renal Cell Carcinoma
Glutathione
Multiple Drug Resistance
Enzymes
Drug Therapy
Cell Line
Neoplasms

Keywords

  • Glutathione
  • Human renal cell carcinoma
  • Multidrug resistance
  • P-170 glycoprotein

ASJC Scopus subject areas

  • Urology

Cite this

P-170 glycoprotein, glutathione and associated enzymes in relation to chemoresistance of primary human renal cell carcinomas. / Mickisch, Gerald H.; Bier, H.; Bergler, W.; Bak, M.; Tschada, R.; Aiken, P.

In: Urologia Internationalis, Vol. 45, No. 3, 1990, p. 170-176.

Research output: Contribution to journalArticle

Mickisch, Gerald H. ; Bier, H. ; Bergler, W. ; Bak, M. ; Tschada, R. ; Aiken, P. / P-170 glycoprotein, glutathione and associated enzymes in relation to chemoresistance of primary human renal cell carcinomas. In: Urologia Internationalis. 1990 ; Vol. 45, No. 3. pp. 170-176.
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AU - Bak, M.

AU - Tschada, R.

AU - Aiken, P.

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