Ozone-induced micronuclei frequency in rat alveolar type II cells

D. Chorvatovičová, P. H.M. Hoet, E. Tátrai, Z. Kováčiková

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Abstract

The effect of ozone, a ubiquitous air pollutant, was tested on cultured pulmonary epithelial type II cells isolated from rats. After 40-hour culture, the cells were exposed for 6 h to 400 ppb of ozone or air. The number of micronucleated cells was counted after the exposure. In each group, 17 000 cells were evaluated. The number of micronucleated cells was significantly increased in the ozone-exposed group (12.24 per 1000 cells) compared to the control group (5.00 per 1000 cells). The results showed the mutagenic effect of ozone exposure on alveolar type II cells, manifested in the increased frequency of their micronuclei.

Original languageEnglish
Pages (from-to)733-736
Number of pages4
JournalPhysiological Research
Volume49
Issue number6
Publication statusPublished - Dec 1 2000

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Keywords

  • Alveolar epithelial type II cells
  • In vitro
  • Micronuclei
  • Ozone

ASJC Scopus subject areas

  • Physiology

Cite this

Chorvatovičová, D., Hoet, P. H. M., Tátrai, E., & Kováčiková, Z. (2000). Ozone-induced micronuclei frequency in rat alveolar type II cells. Physiological Research, 49(6), 733-736.