Oxytocin nerve fibers innervate β-endorphin neurons in the arcuate nucleus of the rat hypothalamus

Attila Csiffáry, Zoltan Ruttner, Zsuzsanna Tóth, Miklós Palkovits

Research output: Contribution to journalArticle

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Fine, varicose oxytocin-containing nerve fibers have been demonstrated in the hypothalamic arcuate nucleus in rats. Using Phaseotus vulgaris leukoagglu- tinin as an anterograde tracer, fine neuronal fibers of paraventricular nucleus origin could be seen throughout the arcuate nucleus. Using double immunostaining, oxytocin-immunoreactive varicose fibers were observed around or in the close vicinity of β-endorphin-immunoreactive neurons. Silver-gold- labeled oxytocin-immunoreactive presynaptic boutons were shown to make synaptic contacts with diaminobenzidine-labeled β-endorphin-immunoreac- tive neurons by electron microscopy. These findings provide morphological evidence for a possible influence of oxytocin on the activity of the brain β- endorphin system at the hypothalamic level.

Original languageEnglish
Pages (from-to)429-435
Number of pages7
Issue number3
Publication statusPublished - Jan 1 1992



  • Anterograde tract tracing
  • Arcuate nucleus
  • Double immunostaining
  • Electron-microscopic immunohistochemistry
  • Oxytocin
  • β-Endorphin

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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