Oxytocin is a precursor of potent behaviourally active neuropeptides

J. Peter H. Burbach, Béla Bohus, Gabor L. Kovács, Jan W. Van Nispen, Henk M. Greven, David de Wied

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

An oxytocin fragment which accumulated during the incubation of oxytocin with brain synaptic membranes was chemically characterized as the hexapeptide pGluAsnCys(Cys)ProLeuGlyNH2 ([pGlu4, Cyt6]OXT-(4-9)). This peptide was approximately a hundred times more potent than oxytocin in attenuating memory consolidation as tested in a passive avoidance test situation; the dose-response relationship was bell-shaped. The des-glycinamide derivative [pGlu4, Cyt6]OXT-(4-8) was nearly as active, but showed a linear dose-response relationship. The data indicate that oxytoxin can act as precursor for potent behaviourally active neuropeptides.

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalEuropean Journal of Pharmacology
Volume94
Issue number1-2
DOIs
Publication statusPublished - Oct 14 1983

    Fingerprint

Keywords

  • Behaviour
  • Memory consolidation
  • Neuropeptides
  • Oxytocin
  • Oxytocin fragment
  • Peptidase

ASJC Scopus subject areas

  • Pharmacology

Cite this

Burbach, J. P. H., Bohus, B., Kovács, G. L., Van Nispen, J. W., Greven, H. M., & de Wied, D. (1983). Oxytocin is a precursor of potent behaviourally active neuropeptides. European Journal of Pharmacology, 94(1-2), 125-131. https://doi.org/10.1016/0014-2999(83)90449-1