Oxytocin is a precursor of potent behaviourally active neuropeptides

J. Peter H Burbach, Béla Bohus, G. Kovács, Jan W. Van Nispen, Henk M. Greven, David de Wied

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

An oxytocin fragment which accumulated during the incubation of oxytocin with brain synaptic membranes was chemically characterized as the hexapeptide pGluAsnCys(Cys)ProLeuGlyNH2 ([pGlu4, Cyt6]OXT-(4-9)). This peptide was approximately a hundred times more potent than oxytocin in attenuating memory consolidation as tested in a passive avoidance test situation; the dose-response relationship was bell-shaped. The des-glycinamide derivative [pGlu4, Cyt6]OXT-(4-8) was nearly as active, but showed a linear dose-response relationship. The data indicate that oxytoxin can act as precursor for potent behaviourally active neuropeptides.

Original languageEnglish
Pages (from-to)125-131
Number of pages7
JournalEuropean Journal of Pharmacology
Volume94
Issue number1-2
DOIs
Publication statusPublished - Oct 14 1983

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Oxytocin
Neuropeptides
Synaptic Membranes
Peptides
Brain

Keywords

  • Behaviour
  • Memory consolidation
  • Neuropeptides
  • Oxytocin
  • Oxytocin fragment
  • Peptidase

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Burbach, J. P. H., Bohus, B., Kovács, G., Van Nispen, J. W., Greven, H. M., & de Wied, D. (1983). Oxytocin is a precursor of potent behaviourally active neuropeptides. European Journal of Pharmacology, 94(1-2), 125-131. https://doi.org/10.1016/0014-2999(83)90449-1

Oxytocin is a precursor of potent behaviourally active neuropeptides. / Burbach, J. Peter H; Bohus, Béla; Kovács, G.; Van Nispen, Jan W.; Greven, Henk M.; de Wied, David.

In: European Journal of Pharmacology, Vol. 94, No. 1-2, 14.10.1983, p. 125-131.

Research output: Contribution to journalArticle

Burbach, JPH, Bohus, B, Kovács, G, Van Nispen, JW, Greven, HM & de Wied, D 1983, 'Oxytocin is a precursor of potent behaviourally active neuropeptides', European Journal of Pharmacology, vol. 94, no. 1-2, pp. 125-131. https://doi.org/10.1016/0014-2999(83)90449-1
Burbach, J. Peter H ; Bohus, Béla ; Kovács, G. ; Van Nispen, Jan W. ; Greven, Henk M. ; de Wied, David. / Oxytocin is a precursor of potent behaviourally active neuropeptides. In: European Journal of Pharmacology. 1983 ; Vol. 94, No. 1-2. pp. 125-131.
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