SAUERSTOFFRADIKALPRODUKTION ALVEOLARER ENTZUNDUNGSZELLEN BEI SARKOIDOSE UND BEI IDIOPATHISCHER LUNGENFIBROSE

Translated title of the contribution: Oxygen radical production of alveolar inflammatory cells in sarcoidosis and idiopathic pulmonary fibrosis (IPF)

J. Strausz, J. Mullerm-Quernheim, H. Steppling, A. Borkowski, R. Ferlinz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Interstitial lung diseases are characterised by chronic inflammatory processes in the lower respiratory tract, parenchymal cell injury and progressive fibrosis of the alveolar structure. Oxygen radicals are claimed to be a major cause of the tissue damage in the lung. We evaluated the spontaneous and stimulated oxygen radical release of bronchoalveolar lavage (BAL) cells in 35 patients with sarcoidosis and 17 patients with IPF. In comparison with the control in both diseases the spontaneous as well as the stimulated oxygen radical release of the BAL cells is markedly increased. In IPF alveolar macrophages produce the bulk part of radicals (84%). Due to their low percentage and in spite of a higher activity on a per cell basis the contribution of neutrophils to the total radical burden is only marginal. In sarcoidosis there is a positive correlation between the oxygen radical release of AM and the CD4/CD8 ratio of BAL lymphocytes. Our results demonstrate that the clinical activity of sarcoidosis and IPF is reflected by the oxygen radical release of BAL cells.

Original languageGerman
Pages (from-to)440-445
Number of pages6
JournalPneumologie
Volume43
Issue number8
Publication statusPublished - 1989

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Alveolar Epithelial Cells
Idiopathic Pulmonary Fibrosis
Sarcoidosis
Bronchoalveolar Lavage
Reactive Oxygen Species
CD4-CD8 Ratio
Interstitial Lung Diseases
Alveolar Macrophages
Respiratory System
Neutrophils
Fibrosis
Lymphocytes
Lung
Wounds and Injuries

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Strausz, J., Mullerm-Quernheim, J., Steppling, H., Borkowski, A., & Ferlinz, R. (1989). SAUERSTOFFRADIKALPRODUKTION ALVEOLARER ENTZUNDUNGSZELLEN BEI SARKOIDOSE UND BEI IDIOPATHISCHER LUNGENFIBROSE. Pneumologie, 43(8), 440-445.

SAUERSTOFFRADIKALPRODUKTION ALVEOLARER ENTZUNDUNGSZELLEN BEI SARKOIDOSE UND BEI IDIOPATHISCHER LUNGENFIBROSE. / Strausz, J.; Mullerm-Quernheim, J.; Steppling, H.; Borkowski, A.; Ferlinz, R.

In: Pneumologie, Vol. 43, No. 8, 1989, p. 440-445.

Research output: Contribution to journalArticle

Strausz, J, Mullerm-Quernheim, J, Steppling, H, Borkowski, A & Ferlinz, R 1989, 'SAUERSTOFFRADIKALPRODUKTION ALVEOLARER ENTZUNDUNGSZELLEN BEI SARKOIDOSE UND BEI IDIOPATHISCHER LUNGENFIBROSE', Pneumologie, vol. 43, no. 8, pp. 440-445.
Strausz, J. ; Mullerm-Quernheim, J. ; Steppling, H. ; Borkowski, A. ; Ferlinz, R. / SAUERSTOFFRADIKALPRODUKTION ALVEOLARER ENTZUNDUNGSZELLEN BEI SARKOIDOSE UND BEI IDIOPATHISCHER LUNGENFIBROSE. In: Pneumologie. 1989 ; Vol. 43, No. 8. pp. 440-445.
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