Gastric mucosal damage was produced by intragastric administration of ethanol (ETOH) or hydrochloric acid (HCl) in rats. The animals were sacrificed at different times after administration of necrotizing agents. The number and severity of gastric mucosal lesions, activities of catalase (CAT), glutathione-peroxidase (GSH-px), superoxide dismutase (SOD), tissue contents of reduced glutathione (red.-GSH) and malondialdehyde (MDA) were measured from the total homogenate of gastric mucosa. It was concluded that the time-sequence changes in development of gastric mucosal damage differed depending on the time following administration of necrotizing agents and that changes in the activities of CAT, GSH-px and SOD, and in the tissue contents of red.-GSH and MDA differed significantly in direction and extent depending on the time following application of ETOH or HCl. Also, changes in the gastric mucosal oxygen free radicals differed in the early phase (from 0 to 15 min) and in the late period (from 15 to 60 min) after administration of necrotizing agents. Finally, changes in gastric mucosal oxygen free radicals represent only one process of gastric mucosal adaptation against chemicals.
|Number of pages||5|
|Journal||European Journal of Gastroenterology and Hepatology|
|Publication status||Published - Jan 1 1991|
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