OXPHOS Defects Due to mtDNA Mutations

Glutamine to the Rescue!

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Mutations in mtDNA associated with OXPHOS defects preclude energy harnessing by OXPHOS. The work of Chen et al. (2018) is previewed, reporting flux pathways of glutamine catabolism in mtDNA mutant cells yielding high-energy phosphates through substrate-level phosphorylation and the influence exerted by the severity of OXPHOS impairment. Mutations in mtDNA associated with OXPHOS defects preclude energy harnessing by OXPHOS. The work of Chen et al. is previewed, reporting flux pathways of glutamine catabolism in mtDNA mutant cells yielding high-energy phosphates through substrate-level phosphorylation and the influence exerted by the severity of OXPHOS impairment.

Original languageEnglish
JournalCell Metabolism
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Glutamine
Mitochondrial DNA
Mutation
Phosphates
Phosphorylation

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

Cite this

OXPHOS Defects Due to mtDNA Mutations : Glutamine to the Rescue! / Chinopoulos, C.

In: Cell Metabolism, 01.01.2018.

Research output: Contribution to journalArticle

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