OXPHOS Defects Due to mtDNA Mutations: Glutamine to the Rescue!

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2 Citations (Scopus)

Abstract

Mutations in mtDNA associated with OXPHOS defects preclude energy harnessing by OXPHOS. The work of Chen et al. (2018) is previewed, reporting flux pathways of glutamine catabolism in mtDNA mutant cells yielding high-energy phosphates through substrate-level phosphorylation and the influence exerted by the severity of OXPHOS impairment. Mutations in mtDNA associated with OXPHOS defects preclude energy harnessing by OXPHOS. The work of Chen et al. is previewed, reporting flux pathways of glutamine catabolism in mtDNA mutant cells yielding high-energy phosphates through substrate-level phosphorylation and the influence exerted by the severity of OXPHOS impairment.

Original languageEnglish
Pages (from-to)1165-1167
Number of pages3
JournalCell Metabolism
Volume27
Issue number6
DOIs
Publication statusPublished - Jun 5 2018

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ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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