Oxovanadium(IV) complexes of salicyl-L-aspartic acid and salicylglycyl-L-aspartic acid

T. Jakusch, Susana Marcão, Lígia Rodrigues, Isabel Correia, João Costa Pessoa, T. Kiss

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The dipeptide and tripeptide analogues salicyl-L-aspartic acid (Sal-L-Asp) and salicylglycyl-L-aspartic acid (SalGly-L-Asp) were synthesized and their protonation and complex formation with VIVO2+ were studied in aqueous solution through the use of pH-potentiometry and spectroscopic (UV-Vis, CD and EPR) techniques. The phenolate terminus proved to be a good anchoring site to promote (i) the metal ion-induced deprotonation and subsequent coordination of the peptide amide group(s) in the pH range 4-5 for the dipeptide analogue, (ii) and in the pH range 5-6 in a very cooperative way for the tripeptide analogue. The results suggest that the presence of good anchoring donors on both sides of the amide groups is responsible for the cooperative deprotonation of the two amide-NH groups.

Original languageEnglish
Pages (from-to)3072-3078
Number of pages7
JournalDalton Transactions
Issue number18
DOIs
Publication statusPublished - Sep 21 2005

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Aspartic Acid
Amides
Deprotonation
Dipeptides
Protonation
Metal ions
Paramagnetic resonance
Peptides
oxovanadium IV

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Oxovanadium(IV) complexes of salicyl-L-aspartic acid and salicylglycyl-L-aspartic acid. / Jakusch, T.; Marcão, Susana; Rodrigues, Lígia; Correia, Isabel; Pessoa, João Costa; Kiss, T.

In: Dalton Transactions, No. 18, 21.09.2005, p. 3072-3078.

Research output: Contribution to journalArticle

Jakusch, T. ; Marcão, Susana ; Rodrigues, Lígia ; Correia, Isabel ; Pessoa, João Costa ; Kiss, T. / Oxovanadium(IV) complexes of salicyl-L-aspartic acid and salicylglycyl-L-aspartic acid. In: Dalton Transactions. 2005 ; No. 18. pp. 3072-3078.
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