Oxidative stress in COPD

Molecular background and clinical monitoring

B. Antus, Zsuzsanna Kardos

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Chronic obstructive pulmonary disease (COPD) is a major and rapidly increasing health problem associated with a chronic inflammatory response, predominantly in small airways and lung parenchyma. Oxidative stress induced by reactive oxygen and nitrogen species (ROS and RNS) plays a central role in the pathophysiology of COPD. There is evidence that several molecules formed during oxidative processes may have the potential to serve as biomarkers of oxidative stress in the airways of patients with COPD. Among these molecules carbon monoxide, ethane and pentane can be measured in the exhaled air, while 8-isoprostane, malondialdehyde, 4-hydroxyhexenal, 4-hyroxynonenal, acrolein, hydrogen peroxide, nitrogen oxides and 3-nitrotyrosine can be detected in exhaled breath condensate and/or sputum supernatant. In this review the molecular background of these processes including the formation of ROS and RNS, the biosynthesis of essential ω-3 and ω-6 polyunsaturated fatty acids as building blocks of lipids in the cellular membranes and their enzymatic and non-enzymatic metabolism to eicosanoids and related compounds have been summarized. Moreover, the formation of oxidative stress markers studied most commonly in the context of COPD has been briefly discussed. The associations between biomarkers and clinical variables have also been highlighted in an attempt to illustrate the potential clinical applicability of these biomarker measurements.

Original languageEnglish
Pages (from-to)627-650
Number of pages24
JournalCurrent Medicinal Chemistry
Volume22
Issue number5
Publication statusPublished - 2015

Fingerprint

Pulmonary diseases
Oxidative stress
Chronic Obstructive Pulmonary Disease
Oxidative Stress
Biomarkers
8-epi-prostaglandin F2alpha
Monitoring
Nitrogen Oxides
Acrolein
Reactive Nitrogen Species
Molecules
Ethane
Eicosanoids
Biosynthesis
Carbon Monoxide
Medical problems
Malondialdehyde
Sputum
Unsaturated Fatty Acids
Metabolism

Keywords

  • Chronic obstructive pulmonary disease
  • Eicosanoids
  • Isofurans
  • Isoprostanes
  • Lipid peroxidation
  • Oxidative stres polyunsaturated fatty acids
  • Reactive oxygen and nitrogen species

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Medicine(all)

Cite this

Oxidative stress in COPD : Molecular background and clinical monitoring. / Antus, B.; Kardos, Zsuzsanna.

In: Current Medicinal Chemistry, Vol. 22, No. 5, 2015, p. 627-650.

Research output: Contribution to journalArticle

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