Oxidative stress and accelerated vascular aging: Implications for cigarette smoking

Anna Csiszar, Andrej Podlutsky, Michael S. Wolin, Gyorgy Losonczy, Pal Pacher, Zoltan Ungvari

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Cigarette smoking is the major cause of preventable morbidity and mortality in the United States and constitutes a major risk factor for atherosclerotic vascular disease, including coronary artery disease and stroke. Increasing evidence supports the hypothesis that oxidative stress and inflammation provide the pathophysiological link between cigarette smoking and CAD. Previous studies have shown that cigarette smoke activates leukocytes to release reactive oxygen and nitrogen species (ROS/RNS) and secrete pro-inflammatory cytokines, increases the adherence of monocytes to the endothelium and elicits airway inflammation. Here we present an overview of the direct effects of water-soluble cigarette smoke constituents on endothelial function, vascular ROS production and inflammatory gene expression. The potential pathogenetic role of peroxynitrite formation, and downstream mechanisms including poly (ADP-ribose) polymerase (PARP) activation in cardiovascular complications in smokers are also discussed.

Original languageEnglish
Pages (from-to)3128-3144
Number of pages17
JournalFrontiers in Bioscience
Volume14
Issue number8
DOIs
Publication statusPublished - Jan 1 2009

Keywords

  • Adp-ribose
  • Cigarette smoking
  • Endothelium
  • Gene expression
  • Inflammation
  • Parp
  • Parp-1
  • Peroxynitrite
  • Poly polymerase
  • Redox status
  • Senescence
  • Smokers
  • Tobacco

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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