Oxidative folding of proteins

M. Narayan, E. Welker, W. J. Wedemeyer, H. A. Scheraga

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

The oxidative folding of proteins is reviewed and illustrated with bovine pancreatic ribonuclease A (RNase A). The mutual effects of conformational folding and disulfide bond regeneration are emphasized, particularly the 'locking in' of native disulfide bonds by stable tertiary structure in disulfide intermediates. Two types of structured metastable disulfide species are discerned, depending on the relative protection of their disulfide bonds and thiol groups. Four generic pathways for oxidative folding are identified and characterized.

Original languageEnglish
Pages (from-to)805-812
Number of pages8
JournalAccounts of Chemical Research
Volume33
Issue number11
DOIs
Publication statusPublished - 2000

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Disulfides
Pancreatic Ribonuclease
Proteins
Sulfhydryl Compounds

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Narayan, M., Welker, E., Wedemeyer, W. J., & Scheraga, H. A. (2000). Oxidative folding of proteins. Accounts of Chemical Research, 33(11), 805-812. https://doi.org/10.1021/ar000063m

Oxidative folding of proteins. / Narayan, M.; Welker, E.; Wedemeyer, W. J.; Scheraga, H. A.

In: Accounts of Chemical Research, Vol. 33, No. 11, 2000, p. 805-812.

Research output: Contribution to journalArticle

Narayan, M, Welker, E, Wedemeyer, WJ & Scheraga, HA 2000, 'Oxidative folding of proteins', Accounts of Chemical Research, vol. 33, no. 11, pp. 805-812. https://doi.org/10.1021/ar000063m
Narayan, M. ; Welker, E. ; Wedemeyer, W. J. ; Scheraga, H. A. / Oxidative folding of proteins. In: Accounts of Chemical Research. 2000 ; Vol. 33, No. 11. pp. 805-812.
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