Oxidative damage of red blood cells in haemolytic uraemic syndrome

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Changes in red blood cell (RBC) lipid peroxidation [measured by malonyl dialdehyde (MDA) concentration], glutathione (GSH) metabolism, antioxidant enzyme activities (catalase, superoxide dismutase, glutathione peroxidase) and haemoglobin (Hb) metabolites (metHb, carboxy Hb) were studied in six children with post-enteropathic (D+) haemolytic uraemic syndrome (HUS) and ten controls. The in vitro effect of hydrogen peroxide [acetyl-phenylhydrazine (APH) test] on GSH and Hb metabolism was also investigated. MDA levels were significantly higher and the antioxidant enzyme activities were lower in HUS patients than in the controls (P

Original languageEnglish
Pages (from-to)26-29
Number of pages4
JournalPediatric Nephrology
Volume8
Issue number1
DOIs
Publication statusPublished - Feb 1994

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Hemolytic-Uremic Syndrome
Hemoglobins
Erythrocytes
Antioxidants
Enzymes
Glutathione Peroxidase
Catalase
Hydrogen Peroxide
Lipid Peroxidation
Superoxide Dismutase
Glutathione

Keywords

  • Antioxidant enzymes
  • Glutathione
  • Haemolytic uraemic syndrome
  • Malonyl dialdehyde

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Nephrology

Cite this

Oxidative damage of red blood cells in haemolytic uraemic syndrome. / Túri, S.; Németh, I.; Vargha, Ilona; Matkovics, B.

In: Pediatric Nephrology, Vol. 8, No. 1, 02.1994, p. 26-29.

Research output: Contribution to journalArticle

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